In intensive care patients with sepsis, are extended (prolonged) infusions of cefepime, compared to conventional intermittent dosing, more effective in achieving and maintaining plasma concentrations above pharmacodynamic breakpoints?

The Alfred0 sites30 target enrollmentJanuary 28, 2009

Overview

No summary available.

Registry

who.int

Start Date

January 28, 2009

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

The Alfred

•An adult intensive care patient who: Has been prescribed cefepime according to The Alfred Intensive Care Unit (ICU) Antibiotic Guidelines (ie. after 7 days of hospital admission and requiring empiric or directed anti\-microbial treatment); Is likely to remain in ICU for at least three days from enrolment; Has an arterial line already in situ for blood sampling.

•1\. Any documented allergy or adverse reaction to cefepime or other cephalosporin antibiotic or significant / serious adverse reaction to other beta\-lactam or monobactam antibiotics which would normally preclude the prescribing of cefepime according to the Alfred ICU Antibiotic Guidelines.
•2\. Moderate to severe renal impairment (calculated estimated glomular filtration ratre (eGRF) \<30mL/min at enrolment) or need for continous renal replacement therapy or intermittent heamodialysis.
•3\. Patients with significant burns (ie. greater than 15% body surface area)
•4\. Patients with extracorporeal circuits (eg. extracorporeal membranous oxygenation, ventricular assist devices)
•5\. All transplant patients including solid organ and bone marrow transplants
•6\. Pregnancy
•7\. Inclusion in other study protocols which preclude enrolment in this study.