Effects of Dexmedetomidine on Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery

Not Applicable

Completed

• Conditions: Lung Cancer; Video-assisted Thoracoscopic Surgery
• Interventions: Drug: Normal saline; Drug: Dexmedetomidine

• Registration Number: NCT02537249
• Lead Sponsor: Yonsei University

Brief Summary

Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) will be enrolled. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QoR-40) questionnaire before their surgery and at 24 and 48 hours post op. They will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (PACU).

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2015-08
• Study First Submitted: 2015-08-24
• Study First Submitted QC: 2015-08-31
• Study First Posted: 2015-09-01
• Status Verified: 2015-11
• Primary Completion: 2015-11
• Study Completion: 2015-11
• Last Update Submitted: 2015-11-09
• Last Update Posted: 2015-11-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 111

Inclusion Criteria

1. The inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer
2. Adults above 20 years of age and providing informed consent.
3. American Society of Anesthesiologists (ASA) Physical class II, & III patients

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Exclusion Criteria

1. severe functional liver or kidney disease
2. history of chronic pain requiring opioid treatment
3. arrhythmia or received treatment with antiarrythmic drug .
4. severe bradycardia (HR < 45 bpm) and AV block
5. pathologic esophageal lesion (esophageal stricture or varix )
6. pregnancy
7. psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire
8. History of alcohol or drug abuse

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline 0.9%	Normal saline	-
Dexmedetomidine	Dexmedetomidine	-

Primary Outcome Measures

Name	Time	Method
quality of recovery measured by QoR-40 questionnaire	24 hr after operation
pulmonary function test	24 hr after operation	postoperative lung function assessed by spirometry

Trial Locations

Locations (1)

Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of