A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
- Conditions
- Carcinoma, Non-Small-Cell Lung
- Interventions
- Registration Number
- NCT06875310
- Lead Sponsor
- Mirati Therapeutics Inc.
- Brief Summary
This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untreated, locally advanced or metastatic NSCLC with KRAS G12C mutation
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 630
- Histologically or cytologically confirmed diagnosis of non-squamous NSCLC with evidence of KRAS G12C mutation via tumor tissue and/or circulating tumor deoxyribonucleic acid (ctDNA).
- Locally advanced or metastatic disease.
- Measurable disease via computed tomography (CT) or magnetic resonance imaging (MRI) per RECIST v1.1 criteria of at least 1 lesion.
- No prior systemic anti-cancer therapy given for advanced or metastatic disease.
- Not a candidate for definitive therapy (eg, chemoradiation or complete surgical resection).
- Participants with brain metastases are eligible for enrollment, including those with untreated brain metastases. Brain metastases must be asymptomatic and not in need of immediate local therapy. Any untreated brain metastases must be ≤ 20 mm in diameter.
- Any PD-L1 expression (0 to 100%) as determined by VENTANA PD-L1 (SP263) assay, Agilent PD-L1 IHC 22C3 pharmDx, or Agilent PD-L1 IHC 28-8 pharmDx.
- Participants with an active, known, prior documented, or suspected autoimmune or inflammatory disease.
- Uncontrolled or significant cardiovascular conditions within 6 months prior to enrollment.
- Inadequate bone marrow or liver function or electrocardiogram (ECG) abnormalities.
- Ongoing treatment with concomitant medication known to cause prolonged QTc interval and that cannot be switched to alternative treatment prior to study entry.
- Treatment targeting KRAS G12C mutation (eg, sotorasib, adagrasib) in any setting.
- Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration.
- Other protocol-defined Inclusion/Exclusion criteria apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Adagrasib Adagrasib - Adagrasib Pembrolizumab - Adagrasib Carboplatin - Adagrasib Pemetrexed - Adagrasib Cisplatin - Placebo Pembrolizumab - Placebo Carboplatin - Placebo Pemetrexed - Placebo Placebo - Placebo Cisplatin -
- Primary Outcome Measures
Name Time Method Progression Free Survival (PFS) as Assessed per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 by Blinded Independent Central Review (BICR) Up to 7 years Overall Survival (OS) Up to 7 years
- Secondary Outcome Measures
Name Time Method Overall Response (OR) as Assessed per RECIST v1.1 by BICR Up to 7 years Duration of Response (DOR) as Assessed per RECIST 1.1 by BICR Up to 7 years PFS as Assessed per RECIST v1.1 by Investigator Up to 7 years Number of Participants With Adverse Events (AEs) Up to 90 days from last dose Number of Participants With Serious Adverse Events (SAEs) Up to 90 days from last dose Number of Participants With AEs Leading to Dose Interruption Up to 90 days from last dose Number of Participants With AEs Leading to Dose Reduction Up to 90 days from last dose Number of Participants With AEs Leading to Treatment Discontinuation Up to 90 days from last dose Number of Deaths Up to 90 days from last dose Time to Definitive Deterioration by Non-Small Cell Lung Cancer-Symptom Assessment Questionnaire (NSCLC-SAQ) Total Score Up to 7 years Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-30) Scale/item Score Up to 90 days from last dose
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Trial Locations
- Locations (325)
Local Institution - 0638
🇲🇽Puebla, Mexico
Local Institution - 0215
🇧🇪Hasselt, Limburg, Belgium
Local Institution - 0181
🇲🇽Puebla, Mexico
Local Institution - 0347
🇺🇸Birmingham, Alabama, United States
Local Institution - 0581
🇺🇸Fullerton, California, United States
Local Institution - 0202
🇺🇸Long Beach, California, United States
Local Institution - 0643
🇺🇸Newport Beach, California, United States
Local Institution - 0666
🇺🇸Orange, California, United States
Local Institution - 0623
🇺🇸Santa Barbara, California, United States
Local Institution - 0442
🇺🇸Denver, Colorado, United States
Local Institution - 0651
🇺🇸Gainesville, Florida, United States
Local Institution - 0621
🇺🇸Palm Bay, Florida, United States
Local Institution - 0377
🇺🇸Tamarac, Florida, United States
Local Institution - 0647
🇺🇸Tampa, Florida, United States
Local Institution - 0392
🇺🇸Fort Eisenhower, Georgia, United States
Local Institution - 0031
🇺🇸Marietta, Georgia, United States
Local Institution - 0665
🇺🇸Arlington Heights, Illinois, United States
Local Institution - 0423
🇺🇸Munster, Indiana, United States
Local Institution - 0366
🇺🇸Edgewood, Kentucky, United States
Local Institution - 0566
🇺🇸Louisville, Kentucky, United States
Local Institution - 0644
🇺🇸Shreveport, Louisiana, United States
Local Institution - 0385
🇺🇸Columbia, Maryland, United States
Local Institution - 0019
🇺🇸Boston, Massachusetts, United States
Local Institution - 0437
🇺🇸Worcester, Massachusetts, United States
Local Institution - 0618
🇺🇸White Plains, New York, United States
Local Institution - 0624
🇺🇸Asheville, North Carolina, United States
Local Institution - 0620
🇺🇸Columbus, Ohio, United States
Local Institution - 0657
🇺🇸York, Pennsylvania, United States
Local Institution - 0658
🇺🇸Greenville, South Carolina, United States
Local Institution - 0652
🇺🇸Laredo, Texas, United States
Local Institution - 0622
🇺🇸San Antonio, Texas, United States
Local Institution - 0575
🇦🇷Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
IDIM - Instituto de Investigaciones Metabólicas
🇦🇷Ciudad de Buenos Aires, Buenos Aires, Argentina
Local Institution - 0584
🇦🇷Pilar, Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
🇦🇷ABB, Ciudad Autónoma De Buenos Aires, Argentina
Local Institution - 0571
🇦🇷Buenos Aires, Ciudad Autónoma De Buenos Aires, Argentina
Local Institution - 0573
🇦🇷Caba, Ciudad Autónoma De Buenos Aires, Argentina
Local Institution - 0595
🇦🇷Rosario, Santa Fe, Argentina
Local Institution - 0126
🇦🇺Canberra, Australian Capital Territory, Australia
Tamworth Hospital
🇦🇺North Tamworth, New South Wales, Australia
Local Institution - 0128
🇦🇺Orange, New South Wales, Australia
Local Institution - 0127
🇦🇺Brisbane, Queensland, Australia
Lyell McEwin Hospital
🇦🇺Elizabeth Vale, South Australia, Australia
Frankston Hospital
🇦🇺Frankston, Victoria, Australia
Local Institution - 0121
🇦🇺Melbourne, Victoria, Australia
Local Institution - 0160
🇦🇺Traralgon, Victoria, Australia
Joondalup Health Campus
🇦🇺Joondalup, Western Australia, Australia
Local Institution - 0532
🇦🇹Wels, Oberösterreich, Austria
Local Institution - 0539
🇦🇹Graz, Steiermark, Austria
Local Institution - 0530
🇦🇹Linz, Austria
Local Institution - 0533
🇦🇹Wien, Austria
Local Institution - 0114
🇧🇪Brussels, Bruxelles-Capitale, Région De, Belgium
Local Institution - 0113
🇧🇪Brussels, Bruxelles-Capitale, Région De, Belgium
Local Institution - 0216
🇧🇪Gent, Oost-Vlaanderen, Belgium
Local Institution - 0107
🇧🇪Leuven, Vlaams-Brabant, Belgium
Local Institution - 0109
🇧🇪Liège, Belgium
Local Institution - 0257
🇧🇷Salvador, Bahia, Brazil
Local Institution - 0242
🇧🇷Vitória, Espírito Santo, Brazil
Local Institution - 0244
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Local Institution - 0235
🇧🇷Ijui, Rio Grande Do Sul, Brazil
Local Institution - 0233
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Local Institution - 0238
🇧🇷Santa Cruz do Sul, Rio Grande Do Sul, Brazil
Local Institution - 0243
🇧🇷Porto Velho, Rondonia, Brazil
Local Institution - 0237
🇧🇷Blumenau, Santa Catarina, Brazil
Local Institution - 0245
🇧🇷Itajaí, Santa Catarina, Brazil
Local Institution - 0240
🇧🇷Barretos, São Paulo, Brazil
Local Institution - 0254
🇧🇷Sao Paulo, São Paulo, Brazil
Local Institution - 0241
🇧🇷São Carlos, São Paulo, Brazil
Local Institution - 0239
🇧🇷São José do Rio Preto, São Paulo, Brazil
Local Institution - 0236
🇧🇷Rio de Janeiro, Brazil
Local Institution - 0258
🇧🇷São Paulo, Brazil
Local Institution - 0629
🇧🇬Panagyurishte, Pazardzhik, Bulgaria
Local Institution - 0628
🇧🇬Sofia, Sofia (stolitsa), Bulgaria
Local Institution - 0627
🇧🇬Ruse, Bulgaria
Local Institution - 0635
🇧🇬Stara Zagora, Bulgaria
Local Institution - 0074
🇨🇦Halifax, Nova Scotia, Canada
Local Institution - 0559
🇨🇦Montreal, Quebec, Canada
Local Institution - 0574
🇨🇱Recoleta, Región Metropolitana De Santiago, Chile
Local Institution - 0577
🇨🇱Santiago, Región Metropolitana De Santiago, Chile
Local Institution - 0482
🇨🇳Bengbu, Anhui, China
Local Institution - 0475
🇨🇳Hefei, Anhui, China
Local Institution - 0355
🇨🇳Beijing, Beijing, China
Local Institution - 0491
🇨🇳Beijing, Beijing, China
Local Institution - 0397
🇨🇳Beijing, Beijing, China
Local Institution - 0490
🇨🇳Chongqing, Chongqing, China
Local Institution - 0362
🇨🇳Fuzhou Fujian, Fujian, China
Local Institution - 0383
🇨🇳Xiamen, Fujian, China
Local Institution - 0469
🇨🇳Guangzhou, Guangdong, China
Local Institution - 0625
🇨🇳Guangzhou, Guangdong, China
Local Institution - 0356
🇨🇳Shantou, Guangdong, China
Local Institution - 0461
🇨🇳Shenzhen, Guangdong, China
Local Institution - 0352
🇨🇳Shenzhen, Guangdong, China
Local Institution - 0464
🇨🇳Nanning, Guangxi, China
Local Institution - 0472
🇨🇳Shijiazhuang, Hebei, China
Local Institution - 0465
🇨🇳Harbin, Heilongjiang, China
Local Institution - 0626
🇨🇳Nanyang, Henan, China
Local Institution - 0494
🇨🇳Xinxiang, Henan, China
Local Institution - 0373
🇨🇳Wuhan, Hubei, China
Local Institution - 0398
🇨🇳Changsha, Hunan, China
Local Institution - 0371
🇨🇳Nanjing, Jiangsu, China
Local Institution - 0382
🇨🇳Suzhou, Jiangsu, China
Local Institution - 0378
🇨🇳Yangzhou, Jiangsu, China
Local Institution - 0467
🇨🇳Nanchang, Jiangxi, China
Local Institution - 0483
🇨🇳Changchun, Jilin, China
Local Institution - 0473
🇨🇳Shenyang, Liaoning, China
Local Institution - 0479
🇨🇳Shenyang, Liaoning, China
Local Institution - 0493
🇨🇳Shenyang, Liaoning, China
Local Institution - 0474
🇨🇳Jinan, Shandong, China
Local Institution - 0359
🇨🇳Linyi, Shandong, China
Local Institution - 0470
🇨🇳Shanghai, Shanghai, China
Local Institution - 0381
🇨🇳Shanghai, Shanghai, China
Local Institution - 0353
🇨🇳Taiyuan, Shanxi, China
Local Institution - 0384
🇨🇳Cheng Du, Sichuan, China
Local Institution - 0667
🇨🇳Chengdu, Sichuan, China
Local Institution - 0460
🇨🇳Tianjin, Tianjin, China
Local Institution - 0462
🇨🇳Hangzhou, Zhejiang, China
Local Institution - 0492
🇨🇳Hangzhou, Zhejiang, China
Local Institution - 0463
🇨🇳Hangzhou, Zhejiang, China
Local Institution - 0374
🇨🇳Linhai, Zhejiang, China
Local Institution - 0354
🇨🇳Shanghai, China
Local Institution - 0580
🇨🇴Medellín, Antioquia, Colombia
Local Institution - 0171
🇨🇴Rionegro, Antioquia, Colombia
Local Institution - 0191
🇨🇴Puerto Colombia, Atlántico, Colombia
Local Institution - 0253
🇨🇴Valledupar, Cesar, Colombia
Local Institution - 0167
🇨🇴Montería, COR, Colombia
Local Institution - 0671
🇨🇴Bogota, Cundinamarca, Colombia
Local Institution - 0189
🇨🇴Bogotá, Distrito Capital De Bogotá, Colombia
Local Institution - 0170
🇨🇴Floridablanca, Santander, Colombia
Local Institution - 0173
🇨🇴Cali, Valle Del Cauca, Colombia
Local Institution - 0619
🇭🇷Dubrovnik, Dubrovačko-neretvanska Županija, Croatia
Local Institution - 0664
🇭🇷Rijeka, Primorsko-goranska Županija, Croatia
Local Institution - 0639
🇭🇷Split, Splitsko-dalmatinska Županija, Croatia
Local Institution - 0567
🇭🇷Osijek, Croatia
Local Institution - 0585
🇭🇷Zagreb, Croatia
Local Institution - 0159
🇫🇷Mulhouse, Alsace, France
Local Institution - 0296
🇫🇷Caen, Calvados, France
Local Institution - 0605
🇫🇷Dijon, Côte-d'Or, France
Local Institution - 0512
🇫🇷Brest, Finistère, France
Local Institution - 0558
🇫🇷Montpellier, Hérault, France
Local Institution - 0220
🇫🇷La Tronche, Isère, France
Local Institution - 0139
🇫🇷Saint-Herblain, Loire-Atlantique, France
Local Institution - 0560
🇫🇷Angers, Maine-et-Loire, France
Local Institution - 0589
🇫🇷Vandoeuvre lès Nancy, Meurthe-et-Moselle, France
Local Institution - 0636
🇫🇷Marseille, Provence-Alpes-Côte-d'Azur, France
Local Institution - 0552
🇫🇷Amiens, Somme, France
Local Institution - 0213
🇫🇷Villejuif, Val-de-Marne, France
Local Institution - 0134
🇫🇷Clermont-Ferrand, France
Local Institution - 0604
🇫🇷Limoges, France
Local Institution - 0164
🇫🇷Marseille, France
Local Institution - 0133
🇫🇷Paris, France
Local Institution - 0158
🇫🇷Paris, France
Local Institution - 0513
🇫🇷Boulogne-Billancourt, Île-de-France, France
Local Institution - 0534
🇩🇪Esslingen, Baden-Württemberg, Germany
Local Institution - 0670
🇩🇪Ulm, Baden-Württemberg, Germany
Local Institution - 0557
🇩🇪München, Bayern, Germany
Local Institution - 0518
🇩🇪Frankfurt, Hessen, Germany
Local Institution - 0535
🇩🇪Gießen, Hessen, Germany
Local Institution - 0520
🇩🇪Hannover, Niedersachsen, Germany
Local Institution - 0527
🇩🇪Oldenburg, Niedersachsen, Germany
Local Institution - 0603
🇩🇪Herne, Nordrhein-Westfalen, Germany
Local Institution - 0523
🇩🇪Köln, Nordrhein-Westfalen, Germany
Local Institution - 0522
🇩🇪Halle, Sachsen-Anhalt, Germany
Local Institution - 0521
🇩🇪Flensburg, Schleswig-Holstein, Germany
Local Institution - 0524
🇩🇪Gera, Thüringen, Germany
Local Institution - 0551
🇩🇪Jena, Thüringen, Germany
Local Institution - 0526
🇩🇪Berlin, Germany
Local Institution - 0537
🇩🇪Berlin, Germany
Local Institution - 0528
🇩🇪Hemer, Germany
Local Institution - 0517
🇩🇪Stuttgart, Germany
Local Institution - 0525
🇩🇪Wuerzburg, Germany
Local Institution - 0608
🇬🇷Athens, Attikí, Greece
Local Institution - 0612
🇬🇷Athens, Attikí, Greece
Local Institution - 0609
🇬🇷Larissa, Thessalía, Greece
Local Institution - 0379
🇭🇰Hksar, Hong Kong
Local Institution - 0466
🇭🇰Hksar, Hong Kong
Local Institution - 0601
🇭🇺Gyor, Győr-Moson-Sopron, Hungary
Local Institution - 0144
🇭🇺Gyöngyös, Heves, Hungary
Local Institution - 0157
🇭🇺Tatabánya, Komárom-Esztergom, Hungary
Local Institution - 0593
🇭🇺Kaposvár, Somogy, Hungary
Local Institution - 0143
🇭🇺Farkasgyepu, Veszprém, Hungary
Local Institution - 0151
🇭🇺Budapest, Hungary
Local Institution - 0140
🇭🇺Budapest, Hungary
Local Institution - 0222
🇮🇳Visakhapatnam, Andhra Pradesh, India
Local Institution - 0312
🇮🇳New Delhi, Delhi, India
Local Institution - 0511
🇮🇳New Delhi, Delhi, India
Local Institution - 0135
🇮🇳New Delhi, Delhi, India
Local Institution - 0136
🇮🇳Ahmedabad, Gujarat, India
Local Institution - 0230
🇮🇳Ahmedabad, Gujarat, India
Local Institution - 0155
🇮🇳Thiruvananthapuram, Kerala, India
Local Institution - 0154
🇮🇳Mumbai, Maharashtra, India
Local Institution - 0226
🇮🇳Bhubaneswar, Odisha, India
Local Institution - 0224
🇮🇳Madurai, Tamil Nadu, India
Local Institution - 0663
🇮🇳Hyderabad, Telangana, India
Local Institution - 0153
🇮🇳Varanasi, Uttar Pradesh, India
Local Institution - 0161
🇮🇳Howrah, West Bengal, India
Local Institution - 0221
🇮🇳Kolkata, West Bengal, India
Local Institution - 0661
🇮🇳Hyderabad, India
Local Institution - 0102
🇮🇪Cork, Ireland
Local Institution - 0476
🇮🇪Dublin, Ireland
Local Institution - 0101
🇮🇪Dublin, Ireland
Local Institution - 0100
🇮🇪Dublin, Ireland
Local Institution - 0106
🇮🇪Dublin, Ireland
Local Institution - 0597
🇮🇱Petah Tikva, HaMerkaz, Israel
Local Institution - 0596
🇮🇱Ramat Gan, HaMerkaz, Israel
Local Institution - 0600
🇮🇱Zerifin, HaMerkaz, Israel
Local Institution - 0544
🇮🇱Jerusalem, Yerushalayim, Israel
Local Institution - 0613
🇮🇱Haifa, Ḥeifā, Israel
Local Institution - 0067
🇮🇹Meldola, Emilia-Romagna, Italy
Local Institution - 0066
🇮🇹Naples, Napoli, Italy
Local Institution - 0070
🇮🇹Orbassano, Piemonte, Italy
Local Institution - 0071
🇮🇹Bari, Puglia, Italy
Local Institution - 0068
🇮🇹Rome, Roma, Italy
Local Institution - 0069
🇮🇹Firenze, Toscana, Italy
Local Institution - 0588
🇮🇹Genova, Italy
Local Institution - 0073
🇮🇹Padova, Italy
Local Institution - 0156
🇮🇹Parma, Italy
Local Institution - 0543
🇮🇹Pavia, Italy
Local Institution - 0556
🇮🇹Varese, Italy
Local Institution - 0607
🇯🇵Nagoya, Aichi, Japan
Local Institution - 0305
🇯🇵Nagoya, Aichi, Japan
Local Institution - 0298
🇯🇵Sapporo, Hokkaido, Japan
Local Institution - 0304
🇯🇵Kanazawa, Ishikawa, Japan
Local Institution - 0302
🇯🇵Sagamihara, Kanagawa, Japan
Local Institution - 0369
🇯🇵Yokohama, Kanagawa, Japan
Local Institution - 0301
🇯🇵Sendai, Miyagi, Japan
Local Institution - 0306
🇯🇵Kashihara, Nara, Japan
Local Institution - 0368
🇯🇵Kurashiki, Okayama, Japan
Local Institution - 0642
🇯🇵Hirakata, Osaka, Japan
Local Institution - 0303
🇯🇵Hidaka, Saitama, Japan
Local Institution - 0300
🇯🇵Ina-machi, Saitama, Japan
Local Institution - 0606
🇯🇵Hamamatsu, Shizuoka, Japan
Local Institution - 0299
🇯🇵Shimotsuga, Tochigi, Japan
Local Institution - 0343
🇯🇵Toyoma, Toyama, Japan
Local Institution - 0542
🇯🇵Iwakuni, Yamaguchi, Japan
Local Institution - 0307
🇯🇵Akashi, Japan
Local Institution - 0346
🇯🇵Aomori, Japan
Local Institution - 0310
🇯🇵Fukuoka, Japan
Local Institution - 0367
🇯🇵Fukushima, Japan
Local Institution - 0308
🇯🇵Kumamoto, Japan
Local Institution - 0297
🇯🇵Osaka, Japan
Local Institution - 0309
🇯🇵Osaka, Japan
Local Institution - 0163
🇰🇷Cheongju-si, Chungcheongbuk-do [Chungbuk], Korea, Republic of
Local Institution - 0227
🇰🇷Namdong-gu, Incheon-gwangyeoksi [Incheon], Korea, Republic of
Local Institution - 0211
🇰🇷Yangsan, Kyǒngsangnam-do, Korea, Republic of
Local Institution - 0186
🇰🇷Busan, Pusan-Kwangyǒkshi, Korea, Republic of
Local Institution - 0165
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0228
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0248
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0146
🇰🇷Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Local Institution - 0583
🇲🇽Saltillo, Coahuila, Mexico
Local Institution - 0176
🇲🇽Mexico City, DIF, Mexico
Local Institution - 0579
🇲🇽Pachuca, Hidalgo, Mexico
Local Institution - 0178
🇲🇽Guadalajara, Jalisco, Mexico
Local Institution - 0591
🇲🇽Monterrey, Nuevo León, Mexico
Local Institution - 0175
🇲🇽Chihuahua, Mexico
Local Institution - 0180
🇲🇽Veracruz, Mexico
Local Institution - 0615
🇳🇱Maastricht, Limburg, Netherlands
Local Institution - 0594
🇳🇱Amsterdam, Noord-Holland, Netherlands
Local Institution - 0205
🇵🇱Wrocław, Dolnośląskie, Poland
Local Institution - 0080
🇵🇱Lublin, Lubelskie, Poland
Local Institution - 0206
🇵🇱Gorlice, Małopolskie, Poland
Local Institution - 0079
🇵🇱Kraków, Małopolskie, Poland
Local Institution - 0077
🇵🇱Prabuty, Pomorskie, Poland
Local Institution - 0209
🇵🇱Poznan, Wielkopolskie, Poland
Local Institution - 0076
🇵🇱Bydgoszcz, Poland
Local Institution - 0078
🇵🇱Katowice, Poland
Local Institution - 0509
🇵🇹Lisbon, Lisboa, Portugal
Local Institution - 0510
🇵🇹Coimbra, Portugal
Local Institution - 0553
🇵🇹Porto, Portugal
Local Institution - 0272
🇷🇴Bucharest, București, Romania
Local Institution - 0261
🇷🇴Bucharest, București, Romania
Local Institution - 0276
🇷🇴Cluj-Napoca, Cluj, Romania
Local Institution - 0268
🇷🇴Florești, Cluj, Romania
Local Institution - 0275
🇷🇴Ovidiu, Constanța, Romania
Local Institution - 0271
🇷🇴Craiova, Dolj, Romania
Local Institution - 0269
🇷🇴Ploiești, Prahova, Romania
Local Institution - 0270
🇷🇴Cluj, Romania
Local Institution - 0273
🇷🇴Cluj, Romania
Local Institution - 0590
🇷🇴Constanța, Romania
Local Institution - 0266
🇷🇴Iași, Romania
Local Institution - 0260
🇷🇴Iași, Romania
Local Institution - 0592
🇷🇴Timișoara, Romania
Local Institution - 0614
🇸🇦Jeddah, Makkah Al Mukarramah, Saudi Arabia
Local Institution - 0602
🇸🇦Riyadh, Saudi Arabia
Local Institution - 0562
🇸🇦Riyadh, Saudi Arabia
Local Institution - 0499
🇪🇸A Coruña, A Coruña [La Coruña], Spain
Local Institution - 0506
🇪🇸Santiago de Compostela, A Coruña [La Coruña], Spain
Local Institution - 0501
🇪🇸Barcelona, Barcelona [Barcelona], Spain
Local Institution - 0497
🇪🇸Hospitalet, Barcelona [Barcelona], Spain
Local Institution - 0505
🇪🇸Barcelona, Catalunya [Cataluña], Spain
Local Institution - 0508
🇪🇸Palma, Illes Balears [Islas Baleares], Spain
Local Institution - 0500
🇪🇸Madrid, Madrid, Comunidad De, Spain
Local Institution - 0503
🇪🇸Madrid, Madrid, Comunidad De, Spain
Local Institution - 0496
🇪🇸Madrid, Madrid, Comunidad De, Spain
Local Institution - 0498
🇪🇸Majadahonda, Madrid, Comunidad De, Spain
Local Institution - 0669
🇪🇸Pontevedra, Pontevedra [Pontevedra], Spain
Local Institution - 0640
🇪🇸Valencia, València, Spain
Local Institution - 0504
🇪🇸Madrid, Spain
Local Institution - 0502
🇪🇸Málaga, Spain
Local Institution - 0507
🇪🇸Sevilla, Spain
Local Institution - 0495
🇪🇸València, Spain
Local Institution - 0536
🇨🇭Münsterlingen, Switzerland
Chi Mei Hospital - Liouying Branch
🇨🇳Tainan City, Tainan, Taiwan
Local Institution - 0631
🇨🇳Taipei City, Taipei, Taiwan
Taipei Medical University Shuang Ho Hospital
🇨🇳New Taipei, Taiwan
Local Institution - 0335
🇨🇳Tainan, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Local Institution - 0565
🇹🇭Muang, Khon Kaen, Thailand
Local Institution - 0563
🇹🇭Bangkok, Krung Thep Maha Nakhon, Thailand
Local Institution - 0564
🇹🇭Hatyai, Songkhla, Thailand
Local Institution - 0548
🇹🇷Stanbul, İstanbul, Turkey
Local Institution - 0199
🇹🇷Izmir, Karsiyaka, İzmir, Turkey
Local Institution - 0197
🇹🇷Adana, Turkey
Local Institution - 0201
🇹🇷Ankara, Turkey
Local Institution - 0198
🇹🇷Ankara, Turkey
Local Institution - 0194
🇹🇷Ankara, Turkey
Local Institution - 0549
🇹🇷Istanbul, Turkey
Local Institution - 0200
🇹🇷Izmir, Turkey
Local Institution - 0550
🇹🇷Malatya, Turkey
University College London Hospital
🇬🇧London, London, City Of, United Kingdom
Local Institution - 0091
🇬🇧London, London, City Of, United Kingdom
Local Institution - 0092
🇬🇧Birmingham, United Kingdom
Local Institution - 0090
🇬🇧Guildford, United Kingdom
Local Institution - 0545
🇬🇧Guildford, United Kingdom
Local Institution - 0093
🇬🇧Manchester, United Kingdom