Paired pulse TMS-EEG in epilepsy: improving the diagnostics process

Completed

Conditions: convulsion
epilepsy
10039911

Registration Number: NL-OMON47679

Lead Sponsor: niversiteit Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 175

Inclusion Criteria

1) Patients presenting with a first (epileptic) seizure
* Presentation of a first (epileptic) seizure
* Ability to understand and comply with the instructions for the TMS session
, 2) Healthy controls
* Ability to understand and comply with the instructions for the TMS session

Exclusion Criteria

* Younger than 18 years
* Contra-indications of TMS (although not absolute): (possibility of)
pregnancy, metal objects in brain/skull, cochlear implant, deep brain
stimulator, history of spinal cord surgery, drains in the spinal cord or
ventricles, use of seizure threshold lowering or enhancing medication
* Follow-up impossible due to logistical reasons, In addition, healthy
subjects are excluded if they have a personal history of epilepsy or if they
have a lesion in the brain, be it vascular, traumatic, infectious or metabolic.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters are the characteristics of the MEP (resting motor<br /><br>threshold (rMT) and long intracortical inhibition (LICI)) and TEP (amplitude<br /><br>and latency of peaks).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include additional signal analysis methods applied<br /><br>on the MEP and TEP. For example, wavelet analysis of early and late TEPs and<br /><br>the spatio-temporal characteristics of the TEP.<br /><br><br /><br>Other study parameters which are documented include: age, gender, handedness,<br /><br>seizure history, type of epilepsy; generalized or focal (if diagnosis epilepsy<br /><br>is confirmed afterwards), EEG abnormalities (if applicable) and MRI<br /><br>abnormalities (if applicable).</p><br>