Dubbel puls TMS-EEG bij epilepsie: het evalueren van de therapeutische werkzaamheid

Recruiting

Conditions: epilepsyepilepsietranscranial magenetic stimulation (TMS)transcraniële magneetstimulatie (TMS)

Registration Number: NL-OMON28473

Lead Sponsor: niversity of Twente

Brief Summary: /A

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 80

Inclusion Criteria

• Diagnosis of epilepsy, either generalized or focal

• Drug naïve, no prior use of AEDs

Exclusion Criteria

• Younger than 18 years

• Contra-indications of TMS (although not absolute): (possibility of) pregnancy, metal objects in brain/skull, cochlear implant, deep brain stimulator, history of spinal cord surgery, drains in the spinal cord or ventricles, use of seizure threshold lowering medication

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The main study parameters are the presence and characteristics of the TMS-EMG (MEP) and TMS-EEG (TEP) response.<br><br /><br /><br>1) MEP response<br /><br>• Resting motor threshold (rMT) - Tesla<br /><br>• Long intracortical inhibition (LICI) - percentage ratio of the mean peak-to-peak amplitude of the response to the second test pulse (TR) and the first conditioning pulse (CR) at each ISI (TR/CR%)<br><br /><br /><br>2) TEP response<br /><br>• Amplitude of peaks - microV<br /><br>• Latencies of peaks - ms

Secondary Outcome Measures

Name	Time	Method
Additional signal analysis methods applied on the MEP and TEP. For example, wavelet analysis of early and late TEPs and the spatio-temporal characteristics of the TEP.