Dubbel puls TMS-EEG bij epilepsie: verbeteren van de diagnostiek
Recruiting
- Conditions
- epilepsyepilepsietranscranial magenetic stimulation (TMS)transcraniële magneetstimulatie (TMS)
- Registration Number
- NL-OMON20996
- Lead Sponsor
- niversity of Twente
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 165
Inclusion Criteria
1) Patients presenting with a first (epileptic) seizure
• Presentation of a first (epileptic) seizure
Exclusion Criteria
• Younger than 18 years
• Contra-indications of TMS (although not absolute): (possibility of) pregnancy, metal objects in brain/skull, cochlear implant, deep brain stimulator, history of spinal cord surgery, drains in the spinal cord or ventricles, use of seizure threshold lowering or enhancing medication
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study parameters are the presence and characteristics of the TMS-EMG (MEP) and TMS-EEG (TEP) response.<br><br /><br /><br>1) MEP response<br /><br>• Resting motor threshold (rMT) - Tesla<br /><br>• Long intracortical inhibition (LICI) - percentage ratio of the mean peak-to-peak amplitude of the response to the second test pulse (TR) and the first conditioning pulse (CR) at each ISI (TR/CR%)<br><br /><br /><br>2) TEP response<br /><br>• Amplitude of peaks - microV<br /><br>• Latencies of peaks - ms
- Secondary Outcome Measures
Name Time Method Additional signal analysis methods applied on the MEP and TEP. For example, wavelet analysis of early and late TEPs and the spatio-temporal characteristics of the TEP.