Paired pulse TMS-EEG in epilepsy: improving the evaluation of therapeutic efficacy
Completed
- Conditions
- convulsionepilepsy10039911
- Registration Number
- NL-OMON47189
- Lead Sponsor
- niversiteit Twente
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
Drug naïve epilepsy patients starting with AEDs
* Diagnosis of epilepsy, either generalized or focal
* Drug naïve, no prior use of AEDs
* Ability to understand and comply with the instructions for the TMS sessions
Exclusion Criteria
* Younger than 18 years
* Contra-indications of TMS (although not absolute): (possibility of) pregnancy, metal objects in brain/skull, cochlear implant, deep brain stimulator, history of spinal cord surgery, drains in the spinal cord or ventricles, use of seizure threshold lowering medication
* Follow-up impossible due to logistical reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary study parameters are the characteristics of the MEP (resting motor<br /><br>threshold (rMT) and long intracortical inhibition (LICI)) and TEP (amplitude<br /><br>and latency of peaks).</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters include additional signal analysis methods applied<br /><br>on the MEP and TEP. For example, wavelet analysis of early and late TEPs and<br /><br>the spatio-temporal characteristics of the TEP.<br /><br><br /><br>Other study parameters which are documented include: age, gender, handedness,<br /><br>seizure history, type of epilepsy; generalized or focal, type and dose of AEDs,<br /><br>EEG abnormalities (if applicable) and MRI abnormalities (if applicable).</p><br>