A randomized controlled trial on the use of Nitrous oxide versus conventional intravenous pain relief in minor gynecological procedures

Phase 2

Completed

• Conditions: analgesic efficacy of the patient controlled inhaled Nitrous oxide with intravenous opioids (Pethidine & Midazolam) in reducing pain during minor gynecological operative procedure, including MVA, fractional curettage and dilatation and curettage; Nitrous oxide, Manual vacuum aspiration, Dilatation and curettage, Midazolam, Pethidine

• Registration Number: TCTR20230107003
• Lead Sponsor: Endowment fund, Faculty of Medicine, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-12-04
• Study Start: 2023-01-07
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 106

Inclusion Criteria

1. Female, 18 years of age or older
2. Treat with dilatation and curettage, fractional curettage and MVA
3. Able to self-controlled inhaled Nitrous oxide
4. Volunteer to participate

Exclusion Criteria

1. hemodynamic unstable
2. contraindication for Nitrous oxide or Pethidine/Midazolam such as history of severe respiratory or cardiac disease, thyroid disease, neurological disorder, renal disorder
3. upper respiratory infections or sinus blockage, recent history of middle or inner ear surgery, pneumothorax or intestinal obstruction
4. ASA physical status III/IV
5. history of curettage

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain score during procedure, immediately post-procedure, 30-mins post-procedure Numerical Rating Scale

Secondary Outcome Measures

Name	Time	Method
satisfactory level, side effects, discharge time post-procedure questionnaire interview