Serum Vitamin D Levels and Pregnancy Rates in Women Undergoing Elective Frozen Embryo Transfer (eFET)
- Conditions
- Pregnancy
- Interventions
- Procedure: frozen embryo transfer
- Registration Number
- NCT02361710
- Lead Sponsor
- Bahceci Clinic
- Brief Summary
The aim of this study is determining the affects of serum vitamin D levels to implantation and clinical pregnancy rates in women undergoing elective vitrified/thawed embryo transfer. Two groups will be identified according to the serum vitamin D levels on eFET transfer day and later on implantation, clinical pregnancy and ongoing pregnancy rates will be compared between those groups
- Detailed Description
In the last decade there have been growing evidence about Vitamin D receptors and their role in female genital tract. But these studies are yet not well designed and the results should be interpreted cautiously. Although some of these studies advocating the Vitamin D deficiency as an negative circumstance on pregnancy rates some of the others don't agree. According to contradictory results understanding the actual role of those receptors needs more observation.
Latest retrospective analyse postulated that, vitamin D deficiency in fresh single embryo transfer cycles may reduce pregnancy rates mediated by endometrium or ovarian reserve and stimulation characteristics.
For this reason the investigators aimed to explore the effect of serum Vitamin D levels on pregnancy rates in infertile population undergoing frozen embryo transfer.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 200
- 18 years to 35 years age, a frozen ET with 1 Day 5 (blastocyst stage) embryo
- Infertile women undergoing ICSI (intracytoplasmic sperm injection) cycle
- Factors affecting fertility are Tubal
- Unexplained or ovulatory disturbances,
- Need to do Preimplantation Genetic Diagnosis
- Presence of endometriosis and adenomyosis
- Severe male factor infertility
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description vitamin D deficient patients frozen embryo transfer Serum 25- (hydroxide) OH Vitamin D levels \<20ng/L undergoing Frozen embryo transfer (Vitamin D levels are measured on the day of embryo transfer) vitamin D sufficient patients frozen embryo transfer Serum 25- (hydroxide) OH Vitamin D levels \>20ng/L undergoing Frozen embryo transfer (Vitamin D levels are measured on the day of embryo transfer)
- Primary Outcome Measures
Name Time Method clinical pregnancy rate 4 weeks after embryo transfer The presence of intrauterine gestational sac at 7 weeks of gestation
- Secondary Outcome Measures
Name Time Method implantation rates 3 weeks after embryo transfer number of gestational sacs per transferred embryo.
ongoing pregnancy rates 18 weeks after embryo transfer Pregnancy that had completed ≥20 weeks of gestation
Trial Locations
- Locations (1)
Bahceci Fulya IVF Center
🇹🇷Istanbul, Fulya, Turkey