Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients
Completed
- Conditions
- Carotid Stenosis
- Registration Number
- NCT03202823
- Lead Sponsor
- Centre Hospitalier Universitaire Dijon
- Brief Summary
Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 204
Inclusion Criteria
- Patients who have provided explicit consent
- Patients older than 18 years
- Patients about to undergo surgery for carotid stenosis
- Haemoglobin ≥ 7g/dl at the time the sample is taken
- Respect the maximum volume of blood taken (treatment + research) in 30 days
SPECIFIC TO DIABETICS
- Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier
Exclusion Criteria
- Patients under guardianship
- Patients without health insurance cover
- Pregnant or breast-feeding women
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects Baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chu Dijon Bourgogne
🇫🇷Dijon, France
Chu Dijon Bourgogne🇫🇷Dijon, France