Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

Completed

• Conditions: Carotid Stenosis
• Interventions: Procedure: blood samples; Procedure: recover samples of atheromatous plaque

• Registration Number: NCT03202823
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-04-13
• Study First Submitted: 2017-06-21
• Study First Submitted QC: 2017-06-26
• Study First Posted: 2017-06-29
• Primary Completion: 2020-12-11
• Study Completion: 2020-12-11
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-25
• Last Update Posted: 2021-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 204

Inclusion Criteria

• Patients who have provided explicit consent
• Patients older than 18 years
• Patients about to undergo surgery for carotid stenosis
• Haemoglobin ≥ 7g/dl at the time the sample is taken
• Respect the maximum volume of blood taken (treatment + research) in 30 days

SPECIFIC TO DIABETICS

• Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier

Exclusion Criteria

• Patients under guardianship
• Patients without health insurance cover
• Pregnant or breast-feeding women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Diabetics	blood samples	-
Non-diabetics	recover samples of atheromatous plaque	-
Non-diabetics	blood samples	-
Diabetics	recover samples of atheromatous plaque	-

Primary Outcome Measures

Name	Time	Method
Change in arachidonic acid metabolism of atheromatous plaques from diabetic versus non-diabetic subjects	Baseline

Trial Locations

Locations (1)

Chu Dijon Bourgogne; 🇫🇷 Dijon, France