Correlation Between Micro Vascular Complications and Severity of Coronary Artery Disease in Type 2 DM

Completed

• Conditions: Patients With Type 2 DM Who Underwent Coronary Angiography Due to Coronary Artery Disease and Presence of Microvascular Complications in Same Patients
• Interventions: Diagnostic Test: albumin creatinine ratio -EGFR-fundus examination- coronary angiography.

• Registration Number: NCT04975828
• Lead Sponsor: Sohag University

Brief Summary

Diabetes is a major cause of morbidity and mortality worldwide and it contributes substantially to healthcare costs. Type 2 Diabetes mellitus is the most common type of diabetes accounting for approximately (90%) of all cases.

Type 2 DM carries a two to six times risk of death from cardiovascular etiologies, such that age adjusted prevalence of white Americans for coronary artery disease (CAD) is double in those with type 2 DM than those without .

Detailed Description

Not available

Study Timeline

• Study Start: 2021-06-01
• Study First Submitted: 2021-07-14
• Study First Submitted QC: 2021-07-14
• Study First Posted: 2021-07-23
• Primary Completion: 2022-01-01
• Study Completion: 2022-01-01
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-15
• Last Update Posted: 2022-02-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

100 Cases were selected with type II (DM) patients who had been admitted for coronary angiography because of suspected (CAD) to the Catheter lab unit of Sohag University Hospital.

Exclusion Criteria

1. Type 1 DM.
2. Smoker.
3. Hypertension.
4. Pregnant women.
5. Patient known non diabetic retinal disease non diabetic. nephropathy or neuropathy.
6. History of familial dyslipidemia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
patients type 2 DM with coronary artery disease and diabetic retinopathy.	albumin creatinine ratio -EGFR-fundus examination- coronary angiography.	-
patients type 2 DM with coronary artery disease and diabetic nephropathy	albumin creatinine ratio -EGFR-fundus examination- coronary angiography.	-
patients type 2 DM with coronary artery disease and diabetic neuropathy.	albumin creatinine ratio -EGFR-fundus examination- coronary angiography.	-
patient type 2 DM with coronary artery disease and non microvascular complications.	albumin creatinine ratio -EGFR-fundus examination- coronary angiography.	-

Primary Outcome Measures

Name	Time	Method
correlation between microvascular complications and severity of coronary disease in type2 DM.	4 months	outcome of study to assess correlation between coronary artery disease and microvascular complications in type 2 DM to early predict coronary artery disease in patient type 2 DM with microvascular complications by non invasive methods as stress ECG or CT coronary angio or cardiac MRI and prevent serious complications as myocardial infarction.; assess microvascular complication as follow albumin creatinine ratio and EGFR to assess. diabetic nephropathy. fundus examination to assess. diabetic retinopathy. assess of coronary artery disease by coronary angiography. assess diabetic nephropathy by neurologic examination.

Trial Locations

Locations (1)

Osama R Elsherief; 🇪🇬 Sohag, Egypt