The Impact of Different Physical Exercise Protocols on Cardio-vascular Efficiency and Quality of Life in Breast Cancer Survivors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer Female
- Sponsor
- ITAB - Institute for Advanced Biomedical Technologies
- Enrollment
- 57
- Primary Endpoint
- Improvement of cardio-vascular efficiency
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
To examine the effects of different physical exercise protocols (aerobic training and resistance training) on cardio-vascular efficiency and quality of life in a population of breast cancer survivors (BCS), not treated with chemotherapy.
Detailed Description
The present study enrolled a population of BCS women who underwent surgical treatment for breast cancer at the "Ospedale G. Bernabeo" of Ortona, Chieti, Italy. The participants were randomized to the following physical exercise protocols: aerobic training, walking or Nordic walking; resistance training. All the participants have been examined utilizing transthoracic echocardiography, carotid ultrasound and photo-plethysmographic method for the analysis of arterial stiffness, before and after the physical exercise protocol (T0-T1). The two-dimensional speckle-tracking analysis was performed with an offline, dedicated software from the apical 4-chambers-view. Moreover, ventricular-arterial coupling, epicardial fat thickness and intima-media thickness were also analyzed. Quality of life was assessed using SF-36 score at T0, T1 and at a mean follow-up of 34 months. Moreover, at follow-up, we evaluated spontaneous physical activity and cardiovascular quality of life using IPAQ and SAQ-7 scores.
Investigators
Francesco Bianco
Researcher
ITAB - Institute for Advanced Biomedical Technologies
Eligibility Criteria
Inclusion Criteria
- •age \< 65 years;
- •history of breast cancer surgery in the previous 12 months;
- •no history of chemotherapy;
- •no ongoing radiotherapy;
- •eventual hormonal therapy;
- •cardiovascular and orthopedic eligibility.
Exclusion Criteria
- •adjuvant chemotherapy;
- •any history of cardiovascular disease;
- •abnormal exercise stress test at the screening;
- •any systemic inflammatory disease or any orthopedic condition potentially limiting the physical training.
Outcomes
Primary Outcomes
Improvement of cardio-vascular efficiency
Time Frame: 12-weeks (from the beginning of physical exercise training)
A composite of the improvement in the following parameters, from pre-treatment values: global longitudinal strain analysis, as assessed by speckle-traking echocardiography; ventricular-arterial coupling, as assessed by echocardiographic single beat method; arterial stiffness (pulse wave velocity, augmentation index), as assessed by photoplethysmographic method
Secondary Outcomes
- Epicardial fat thickness reduction(12-weeks (from the beginning of physical exercise training))
- Intima-media thickness reduction(12-weeks (from the beginning of physical exercise training))
- Improvement of quality of life(12-weeks (from the beginning of physical exercise training); a mean of 34 months from the enrollment)
- Improvement of spontaneous physical activity(a mean of 34 months from the enrollment)
- Improvement of cardiovascular quality of life(a mean of 34 months from the enrollment)