Early Detection of Cognitive Dysfunction in Diabetes

• Conditions: Dementia; DM; MCI

• Registration Number: NCT01830998
• Lead Sponsor: Wuhan General Hospital of Guangzhou Military Command

Brief Summary

The rate of cognitive decline due to ageing is increased 1.5-fold to 2.0-fold in individuals with type 2 diabetes.There are no established specific treatment measures to prevent or ameliorate cognitive impairments in patients with diabetes. we want to detecte early clinical dementia in diabete.

Detailed Description

Clinically relevant cognitive decrements in relation to diabetes mainly occur during two crucial periods in life: the period of brain development in childhood, and the period when the brain undergoes neurodegenerative changes associated with ageing.Potential leads for treatment are to optimise glycaemic control and avoid and treat vascular risk factors.we want to detecte early clinical dementia in diabete by MMSE and Olfactory function.

Study Timeline

• Study Start: 2012-01
• Study First Submitted: 2013-04-01
• Study First Submitted QC: 2013-04-10
• Study First Posted: 2013-04-12
• Status Verified: 2014-12
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Last Update Submitted: 2014-12-09
• Last Update Posted: 2014-12-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Patients with type 2 diabetes(Age>50 years)

Exclusion Criteria

• with stroke or other complications.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MMSE Olfactory function dementia	2 years	MMSE,Olfactory function and PET(fMRI) were observed.

Trial Locations

Locations (3)

tongji Medical University; 🇨🇳 Wuhan, Hubei, China

Wuhan general hospital of Guangzhou Command; 🇨🇳 Wuhan, Hubei, China

Wuhan general hospital of Guangzhou command; 🇨🇳 Wuhan,chongqing, Hubei, China