The effect of food stimuli on the calorie restriction response in healthy subjects
- Conditions
- ouderdomsziekten en verouderingsprocesage-related diseasesdiseases of the elderly1002111210018424
- Registration Number
- NL-OMON32066
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 12
-Caucasian male volunteers
-Age > 18 years and < 70 years
-Body mass index (BMI) > 20 kg/m2 and < 25 kg/m2
-Fasting serum glucose < 6.1 mmol/L
-Any significant chronic or hereditary disease (including renal, hepatic or endocrine disease)
-Any significant abnormal laboratory results found during the medical screening procedure
-Any use of medication (except for NSAID)
-Anosmia or any other (acquired) loss of olfaction (ea. rhinitis)
-Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
-Difficulties to insert an intravenous catheter
-Smoking
-MRI contraindications
-Recent blood donation (within the last 3 months)
-Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>-Fasting endocrine and metabolic serum values<br /><br>-Insulin sensitivity measured by oral glucose tolerance test (OGTT) (area under<br /><br>the curve (AUC) of insulin, C-peptide, free fatty acid (FFA) and glucose)<br /><br>-Glucose and FFA oxidation as determined by indirect calorimetry<br /><br>-Hypothalamic response to oral glucose load as measured by fMRI (functional<br /><br>magnetic resonance imaging)<br /><br>-Anthropometric measurements (weight, waist and hip ratio (WHR), blood<br /><br>pressure, bioelectrical impedance analysis (BIA))</p><br>
- Secondary Outcome Measures
Name Time Method <p>none</p><br>