Measurement of Fibrinogen in Patients With Systemic Inflammatory Response Syndrome (SIRS), Sepsis or Chronicle Liver Disease on Intensive Care Units (ICU)
- Conditions
- SIRSLiver DiseaseSepsis
- Registration Number
- NCT01169168
- Lead Sponsor
- Johann Wolfgang Goethe University Hospital
- Brief Summary
In this study patients with
1. chronicle liver diseases
* primary biliary cirrhosis
* primary sclerosing cholangitis
* alcoholic liver cirrhosis
* hepatitis b or C
* Wilson's disease
* cryptogenic cirrhosis
2. Septic Inflammatory Response Syndrome (SIRS)
* sepsis
* septic shock
3. patients after lysis
should be included
Blood samples will be gathered from the patients to measure fibrinogen with 5 different methods.
The methods are:
* Clauss fibrinogen
* PT-Derived fibrinogen
* immunoturbidimetric method
* heat-precipitated fibrinogen
* Schulz fibrinogen
The result of these tests will be correlated with laboratory values which are gathered in routine and the clinical outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 250
- SIRS
- sepsis
- septic shock
- chronicle liver disease (MELD-Score >10)
- patient after lysis
- patient agrees
- no agreement
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fibrinogen levels from 5 test methods * Clauss fibrinogen
* PT-Derived fibrinogen
* immunoturbidimetric method
* heat-precipitated fibrinogen
* Schulz fibrinogen
- Secondary Outcome Measures
Name Time Method mortality Number of bleedings Number of administered thrombocyte concentrates Number of administered erythrocyte concentrates Number of administered fresh frozen plasma
Trial Locations
- Locations (1)
Johann Wolfgang Goethe University Hospital
🇩🇪Frankfurt, Hessen, Germany