The Effect of Intravenous Lidocaine on Allodynia

Not Applicable

Completed

• Conditions: Pain
• Interventions: Drug: lidocaine

• Registration Number: NCT00659633
• Lead Sponsor: University of Alabama at Birmingham

Brief Summary

The purpose of this study is to study if lidocaine, given intravenously, reduces pain.

Detailed Description

Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.

Study Timeline

• Study First Submitted: 2008-04-14
• Study First Submitted QC: 2008-04-14
• Study First Posted: 2008-04-16
• Study Start: 2008-12
• Primary Completion: 2016-06
• Study Completion: 2016-08
• Results First Submitted: 2017-04-18
• Status Verified: 2017-06
• Results First Submitted QC: 2017-06-06
• Results First Posted: 2017-06-08
• Last Update Submitted: 2017-06-22
• Last Update Posted: 2017-07-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi

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Exclusion Criteria

• History of Substance abuse
• Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis.
• Coronary Artery Disease (CAD): unstable
• Congestive Heart Failure (CHF): unstable
• Heart Arrhythmia: symptomatic
• Chronic Obstructive Pulmonary Disease (COPD)
• Lidocaine Allergy
• Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation.
• Presence of Contraindications for MRI
• Presence of electronically, magnetically, and mechanically activated implants
• Electronically, magnetically, and mechanically activated implants
• Ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators
• Cardiac pacemakers
• Metallic splinters in the eye
• Ferromagnetic haemostatic clips in the central nervous system (CNS)
• Claustrophobia
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Lidocaine	lidocaine	Intravenous lidocaine for neuropathic pain

Primary Outcome Measures

Name	Time	Method
Pain Perception	Participants will be followed from baseline through 128 minutes	Assessing heat pain perception (pain intensity) before, during, and after lidocaine infusion by means of patient self-report using a mechanical slide algometer.; The mechanical slide algometer \[Price et al. (1994)\] looks like a ruler that exposes a red bar with the end-points: no pain (left) and most pain imaginable (right). The use the slider to express their perceived pain. On the back of the ruler a numerical scale ranging from 0 (no pain) to 10 (worst imaginable pain) translates the patient's rating into a numeric scale.

Trial Locations

Locations (1)

University of Alabama at Birmingham; 🇺🇸 Birmingham, Alabama, United States