The Effect of Intravenous Lidocaine on Allodynia (Carl Koller Grant)
Overview
- Phase
- Not Applicable
- Intervention
- lidocaine
- Conditions
- Pain
- Sponsor
- University of Alabama at Birmingham
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Pain Perception
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to study if lidocaine, given intravenously, reduces pain.
Detailed Description
Clinicians use lidocaine intravenously in a fashion that suggests that it might have analgesic effects. Therefore, we test the hypothesis that lidocaine reduces pain intensity in response to experimental pain.
Investigators
Michael Froelich
Associate Proffesor Anesthesiology M.D.
University of Alabama at Birmingham
Eligibility Criteria
Inclusion Criteria
- •Chronic Regional Pain Syndrome diagnostic criteria by the Work Safe BC. vi
Exclusion Criteria
- •History of Substance abuse
- •Other Medications: CRPS patients are expected to be treated for chronic pain, whether the current treatment regimen interferes with sensory motor testing will be determined on a case by case basis.
- •Coronary Artery Disease (CAD): unstable
- •Congestive Heart Failure (CHF): unstable
- •Heart Arrhythmia: symptomatic
- •Chronic Obstructive Pulmonary Disease (COPD)
- •Lidocaine Allergy
- •Diagnostic and Statistical Manual of Mental Disorders (Rev IV): Axis I: Common Axis I disorders include depression, anxiety disorders, bipolar disorder, ADHD, and schizophrenia. Axis II: borderline personality disorder, schizotypal personality disorder, antisocial personality disorder, and mild mental retardation.
- •Presence of Contraindications for MRI
- •Presence of electronically, magnetically, and mechanically activated implants
Arms & Interventions
Lidocaine
Intravenous lidocaine for neuropathic pain
Intervention: lidocaine
Outcomes
Primary Outcomes
Pain Perception
Time Frame: Participants will be followed from baseline through 128 minutes
Assessing heat pain perception (pain intensity) before, during, and after lidocaine infusion by means of patient self-report using a mechanical slide algometer. The mechanical slide algometer \[Price et al. (1994)\] looks like a ruler that exposes a red bar with the end-points: no pain (left) and most pain imaginable (right). The use the slider to express their perceived pain. On the back of the ruler a numerical scale ranging from 0 (no pain) to 10 (worst imaginable pain) translates the patient's rating into a numeric scale.