The Effects of Caffeine on Human Spinal Motoneurons
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Motoneuron excitability (Delta-f)
研究概览
简要总结
This study evaluates the effects of orally ingested, commercially available, coffee (3 mg/kg of caffeine) on the excitability of human spinal motoneurons of the lower leg.
详细描述
Recently, it has been shown that human spinal motoneurons do not simply act as a binary control system. Instead, they are regulated by intrinsic properties that can elicit lingering effects on the descending motoneuron. Caffeine, one of the world's most popular over-the-counter supplements, can potentially augment these characteristics of motoneurons. Using decomposition software and non-invasive, high-density surface electromyography, it is possible to extract the characteristics of these motoneurons. This project will utilize a double-blind, inactive-placebo controlled, crossover design study to examine and quantify the effects of caffeine on motoneuron excitability.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •● Between 18 and 70 years of age
排除标准
- •Significant neurological or orthopedic injuries, which may limit volitional torque generation in the tested muscles.
- •Significant change in the subjects' health or treatment in the past month.
- •Known history of cardiovascular pathology (to include: uncontrolled hypertension, cardiac arrhythmias) or medical restrictions to caffeine ingestion.
- •Allergies or dislike of coffee.
- •Women who are pregnant will be excluded due to potential forces at trunk from pelvic safety harness and due to potential adverse effects of caffeine on the developing child.
- •Women who are breastfeeding will be excluded due potential adverse effects on the breastfeeding infant from caffeine administration.
- •Adults unable to consent, minors, pregnant women, and prisoners will not be included.
结局指标
主要结局
Motoneuron excitability (Delta-f)
时间窗: Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention
Changes in motorneuron excitability, as quantified by Delta-F values. A paired motor unit technique will be utilized (Gorassini et al., 2002). (Typically, these values range from -5 to +10).
次要结局
- Motor Unit Recruitment Threshold(Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention)
- Coherence(Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention)
- Motor Unit Discharge Rate(Measured repeatedly at set intervals; Pre-Intervention & 30, 60, 90 minutes post-Intervention)