Demonstrating Pemetrexed induced Thymidylate Synthase inhibition in non-small cell lung cancer in vivo: a pilot study.
Recruiting
- Conditions
- NSCLC10038666
- Registration Number
- NL-OMON32208
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 12
Inclusion Criteria
Patient age 18 years or older
Histological diagnosis of NSCLC
Scheduled for treatment with pemetrexed
Tumour diameter min. 3cm (to minimize partial volume effects) within the chest
Able to remain supine for 60 minutes
Written informed consent
Exclusion Criteria
Pregnant or lactating patients
Claustrophobia
Patients having metal implants (e.g. pacemakers)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Change of 18F-FLT uptake as measured with time lapse of 4 hrs after pemetrexed.<br /><br>18F-FLT changes versus clinical response measured with RECIST.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable</p><br>