Don't Treat Ghosts: Anti-MRSA Antibiotics in Osteomyelitis Without Identified MRSA
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 365
- 试验地点
- 1
- 主要终点
- Comparison of treatment
研究概览
简要总结
Osteomyelitis is described as infection and inflammation of the long bone or bone marrow, often due to an open wound, operation, or invasive trauma.1 It is invasive and involves hematogenous seeding or contiguous spread of the infectious organism
详细描述
This disease can be classified by location of infection, extent of spread, chronicity, and source of infection.3,4 Osteomyelitis can be caused by a variety of organisms, most commonly gram-positive staphylococci.
Osteomyelitis is associated with a high rate of relapse, high disease burden, and high health care costs.3 Following confirmation of disease via imaging and histopathologic examination, treatment consists of antibiotic therapy and, often, surgical intervention.3,5,6 Treatment with antibiotic therapy is often administered for 4-6 weeks when surgical intervention is not performed.6 Antibiotic selection should be guided by microbiology and antimicrobial susceptibilities.4 Thirty to sixty percent of osteomyelitis cases are caused by Staphylococcus aureus.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •• Admission to any MHS hospital between April 1, 2017 and April 1, 2023
- •> 18 years of age
- •Documented osteomyelitis location of the lower limb via ICD-10 code
- •Documented imaging of lower limb osteomyelitis during index admission
- •Planned intravenous (IV) antibiotics for at least 4 weeks
排除标准
- •• IV antibiotics for less than 24 hours inpatient
- •Planned surgical intervention documented at admission
- •Patients receiving monotherapy with an anti-MRSA agent
- •Positive MRSA culture during index admission
- •Current outpatient antibiotic use on index admission
- •Repeated hospital admission during study period
结局指标
主要结局
Comparison of treatment
时间窗: 180 Days
the comparison of treatment failure between anti-MRSA therapy and no anti-MRSA therapy defined as a composite of hospital readmission for osteomyelitis within 180 days of antibiotic initiation
次要结局
未报告次要终点