Recurrent S. Aureus Infections in Osteoarticular Infections

• Conditions: Staphylococcus Aureus Infection; Bone and Joint Infection
• Interventions: Other: relapse due to S. aureus

• Registration Number: NCT04712123
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Staphylococcus aureus osteoarticular infections, in particular those associated with the presence of implant, relapse in 20% of cases. Currently, the reasons for these relapses are poorly understood, whether on the microbiological or clinical side.

The aim of this study is to improve knowledge on persistence of mechanisms of S. aureus

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-13
• Study First Submitted QC: 2021-01-13
• Study First Posted: 2021-01-15
• Study Start: 2021-08-01
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-19
• Last Update Posted: 2022-01-20
• Primary Completion: 2022-12-01
• Study Completion: 2023-01-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• patients having had an osteoarticular infection with or without material due to S. aureus presenting a recurrence of S. aureus infection

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Exclusion Criteria

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
relapse due to S. aureus	relapse due to S. aureus	patients having had an initial infection due to S. aureus and who present a relapse with persistence of S. aureus

Primary Outcome Measures

Name	Time	Method
rate of patients having had an osteoarticular infection due to S. aureus	between 2015 and 2020	proportion of patients having had an osteoarticular infection due to S. aureus
Description of Bone and Joint Iinfection/Prosthesis Joint Infection	between 2015 and 2020	implant or prosthesis or not, acute/ chronic, bacteriology
Description of patients having had an osteoarticular infection due to S. aureus	between 2015 and 2020	type of patients: age, BMI, comorbidities...

Secondary Outcome Measures

Name	Time	Method
rate of S. aureus strain identical between the initial episode and the relapse	between 2015 and 2020	proportion of relapse due to the same strain of S. aureus than in the initial episode
rate of patients having had a relapse due to persistence of S. aureus	between 2015 and 2020	proportion of patients having had an osteoarticular infection due persistence of S. aureus

Trial Locations

Locations (1)

Hospices Civils de Lyon; 🇫🇷 Lyon, France