NCT01375335暂停4 期
The Effects of Dobutamine on Postoperative Systolic Deformation and Diastolic Function in Patients With Hypertrophic Cardiomyopathy Operated for Aortic Valve Stenosis
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 暂停
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Cardiac output
研究概览
简要总结
The use of dobutamine in postoperative hemodynamic treatment is widespread despite seemingly intact contraction of the heart. This study aims to elucidate the efficacy of low-dose dobutamine infusion in patients in the postoperative phase replacement of the aortic valve.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 19 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-90 years
- •Left ventricular posterior wall =/>12mm
- •Ejection fraction > 45%
- •Sinus rhythm
- •Eligible for aortic valve replacement
排除标准
- •Need for concomitant cardiac bypass operation.
- •Moderate or severe insufficiency of the mitral valve
- •Active endocarditis
- •Insufficient ultrasound window
- •Using B-blockers
- •Liver insufficiency
- •Patients treated with COMT-inhibitors
- •Allergy towards dobutamine
- •Pregnancy
- •Women of fertile age who do not use relevant anti-conception
- •Lacking participant consent
研究组 & 干预措施
Dobutamine
Experimental
干预措施: Dobutamine (Drug)
结局指标
主要结局
Cardiac output
时间窗: From 0 to 90 minutes after drug initiation
Change in cardiac output (l/min) from initiation of study drug or placebo until 90 minutes of infusion.
次要结局
- Mean pulmonary artery pressure(From 0 to 90 minutes after drug initiation.)
- Echocardiography(From 0 minutes to 90 minutes after drug initiation)
- Changes in mixed venous saturation(From 0 minutes to 90 minutes after drug initiation)
- norepinephrine requirement(From 0 minutes to 90 minutes after drug initiation)
- Central venous pressure(From 0 minutes to 90 minutes after drug initiation)
研究者
研究点 (1)
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