Respiratory Effects of Dopamine in the Perioperative Care
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Arterial oxygen partial pressure (PaO2)
研究概览
简要总结
Dopamine is frequently used as an inotropic drug to elevate cardiac output. In addition to the beneficial cardiac effect of this drug, the few previous studies addressing its ability to alter the airway tone reported controversial results.
Thus, the investigators aimed at clarifying the potential of dopamine to alter gas exchange outcomes and the airway tone in patients undergoing cardiac surgeries with cardiopulmonary bypass.
Blood gas parameters, airway resistance, tissue damping and tissue elastance will be measured in the patients before the CPB, immediately after CPB, and 5 min after administration of dopamine (3 mcg/kg/min).
The importance of the research is to reveal whether the beneficial mechanical changes after dopamine administrations are associated with improvements in gas exchange outcomes. Clarification of this research question have scientific relevance and may also improves patient outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cardial surgery patients undergoing cardiopulmonary bypass procedures
排除标准
- •Chronic respiratory diseases, elderly (>80 years)
研究组 & 干预措施
Dopamine group
Cardiac surgery patients receiving dopamine to support their cardiac function (as part of the routine post-operative care).
干预措施: Dopamine administration (Drug)
结局指标
主要结局
Arterial oxygen partial pressure (PaO2)
时间窗: 5 min after administration of dopamine
Partial pressure of oxygen in the blood sample assessed by a blood gas analyser.
Lung mechanics
时间窗: 5 min after administration of dopamine
Airway resistance, lung tissue damping and lung tissue elastance obtained by forced oscillation technique.
Arterial carbon dioxide partial pressure (PaCO2)
时间窗: 5 min after administration of dopamine
Partial pressure of carbon dioxide in the blood sample assessed by a blood gas analyser.
次要结局
- Capnography(5 min after administration of dopamine)
- Intrapulmonary shunt(5 min after administration of dopamine)