Respiratory Effects of Dopamine in the Perioperative Care

Not Applicable

• Conditions: Dopamine; Bronchodilation; Heart; Surgery; Functional Disturbance
• Interventions: Drug: Dopamine administration

• Registration Number: NCT04753008
• Lead Sponsor: Szeged University

Brief Summary

Dopamine is frequently used as an inotropic drug to elevate cardiac output. In addition to the beneficial cardiac effect of this drug, the few previous studies addressing its ability to alter the airway tone reported controversial results.

Thus, the investigators aimed at clarifying the potential of dopamine to alter gas exchange outcomes and the airway tone in patients undergoing cardiac surgeries with cardiopulmonary bypass.

Blood gas parameters, airway resistance, tissue damping and tissue elastance will be measured in the patients before the CPB, immediately after CPB, and 5 min after administration of dopamine (3 mcg/kg/min).

The importance of the research is to reveal whether the beneficial mechanical changes after dopamine administrations are associated with improvements in gas exchange outcomes. Clarification of this research question have scientific relevance and may also improves patient outcomes.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-12-13
• Status Verified: 2021-02
• Study First Submitted: 2021-02-05
• Study First Submitted QC: 2021-02-10
• Last Update Submitted: 2021-02-10
• Study First Posted: 2021-02-12
• Last Update Posted: 2021-02-12
• Primary Completion: 2021-03-31
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Cardial surgery patients undergoing cardiopulmonary bypass procedures

Exclusion Criteria

• Chronic respiratory diseases, elderly (>80 years)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dopamine group	Dopamine administration	Cardiac surgery patients receiving dopamine to support their cardiac function (as part of the routine post-operative care).

Primary Outcome Measures

Name	Time	Method
Arterial oxygen partial pressure (PaO2)	5 min after administration of dopamine	Partial pressure of oxygen in the blood sample assessed by a blood gas analyser.
Lung mechanics	5 min after administration of dopamine	Airway resistance, lung tissue damping and lung tissue elastance obtained by forced oscillation technique.
Arterial carbon dioxide partial pressure (PaCO2)	5 min after administration of dopamine	Partial pressure of carbon dioxide in the blood sample assessed by a blood gas analyser.

Secondary Outcome Measures

Name	Time	Method
Capnography	5 min after administration of dopamine	Time capnography to obtain phase 3 and phase 2 slopes.
Intrapulmonary shunt	5 min after administration of dopamine	Intrapulmonary shunt obtained by the Berggren shunt equation from arterial and central venous blood samples.

Trial Locations

Locations (1)

Barna Babik; 🇭🇺 Szeged, Hungary