Pilot trial evaluating the efficacy of different antibiotic treatments for the treatment of prosthetic joint infection in adults who have undergone joint replacement surgery.

John Hunter Hospital0 个研究点目标入组 60 人开始时间: 2017年1月24日最近更新: 2022年5月2日

适应症

试验速览

暂无简介。

•1) Aged >=18 years
•2) Prosthetic joint infection of the hip or knee (according to IDSA diagnostic criteria)
•3) Acute infection (either a. Diagnosis <4 weeks from date of implantation of prosthesis OR b. Suspected acute haematogenous infection with <3 weeks from symptom onset to diagnosis)
•4) Meet IDSA criteria for DAIR (stable implant, no sinus, absence of septic shock).
•5) One or more identified causative organisms (can be Gram positive, Gram negative or mixed)
•6) Adequate debridement has been performed or is planned (this means an open as opposed to arthroscopic debridement and exchange of modular components)
•7) Initial diagnosis is <21 days prior to randomisation.

•1) Additional diagnosis requiring >2 weeks of IV antibiotics in the opinion of the site PI (e.g. Staphylococcus aureus bacteraemia).
•2) Patient not treated with curative intent.
•3) Patient unlikely to survive for > 12 months (in the opinion of the site PI).
•4) Gram positive rifampicin resistant causative organism.
•5) Gram negative ciprofloxacin resistant causative organism.
•6) At least one causative organism is Proprionibacterium spp., Gram negative anaerobes, Fungi, Mycobacteria.

发起方