Effect of spinal cord and peripheral nerve stimulation on sensory profile and on endogenous pain modulatio

• Conditions: complex regional pain syndrome, peripheral nerve injury, raduculopathy, polyneuropathy; M89.0; G56.4; M54.1; G62.9; G56; G57; G58; Algoneurodystrophy; Radiculopathy

• Registration Number: DRKS00010607
• Lead Sponsor: Abteilung für Schmerzmedizin,Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-09-02
• Study Start: 2016-09-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

Inclusuion criteria was a reported beneficial effect to neurostimulation and the ability to understand the study design.

Exclusion Criteria

Exclusion criteria were no pain relief after SCS or PNS implantation, pain duo to angina pectoris and stump pain after amputation, mental limitations and spasm following neurostimulation.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantitative Sensory Testing (QST, DFNS protocol), conditioned pain modulation (CPM) and skin temperature measurement in the affected area and contralateral were examined at first with inactivated stimulation and then with activated stimulation. QST investigates the function of thick-, thinly- and unmyelinated nerve fibers (A-ß, A-d and C nerve fibers). CPM evaluates the efficacy of diffuse noxious inhibitory controls (DNIC). Temperature measurement is an established indirect technique to detect sympathetic blockade, shown through an increase of skin temperature.

Secondary Outcome Measures

Name	Time	Method
Correlation between this changes and the analgesic effect was assumed.