Community Trial of Zinc Supplementation on Preschool Child Mortality and Morbidity in Southern Nepal
- Conditions
- Nutrition
- Registration Number
- NCT00109551
- Lead Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Brief Summary
The purpose of this study is to determine whether daily supplementation of young children in Nepal with either zinc, iron-folic acid, or both can reduce mortality and morbidity. Young children in Nepal have numerous nutritional deficiencies and high rates of morbidity and mortality. Zinc and/or iron supplementation may be a cost-effective method for reducing these risks.
- Detailed Description
Mortality rates among preschool age children in Nepal and many other developing countries remain high despite significant progress made over the past 20 years. There remain significant nutritional deficiencies in these populations, especially important are vitamin and mineral deficiencies.
Comparisons: In this study, we are comparing the morbidity and mortality experience for children 1-36 months of age randomized to one of four daily supplementation regimens: placebo, zinc alone, iron-folic acid alone, zinc + iron-folic acid.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 58000
- All children 1-35 months of age living in 30 Village Development Committees of Sarlahi District in southern Nepal.
- Parent refusal
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Primary Outcome Measures
Name Time Method Death among children 1-36 months of age
- Secondary Outcome Measures
Name Time Method Incidence rates of selected morbidities including diarrhea, dysentery, acute respiratory infections
Trial Locations
- Locations (3)
Johns Hopkins Bloomberg School of Public Health
🇺🇸Baltimore, Maryland, United States
Cornell University Division of Nutritional Sciences
🇺🇸Ithaca, New York, United States
Nepal Nutrition Intervention Project-Sarlahi
🇳🇵Kathmandu and Sarlahi District, Nepal