Ozonated Water in Treatment of Denture Stomatitis

Not Applicable

Completed

• Conditions: Denture Stomatitis
• Interventions: Other: Ozonated water; Other: Chlorhexidine mouthwash

• Registration Number: NCT06021847
• Lead Sponsor: National Research Centre, Egypt

Brief Summary

The effect of Ozonated water on the treatment of oral stomatitis associated with complete denture wearer in comparison to Chlorhexidine mouthwash

Detailed Description

Compete denture wearers having oral denture stomatitis were divided into two groups. group I used Ozonated water while group II used Chlorhexidine mouthwash. The growth of Candida albicans, the degree inflammation and pain grade were evaluated before starting the treatment then every week till one month. Also

Study Timeline

• Status Verified: 2022-07
• Study Start: 2023-05-01
• Primary Completion: 2023-06-01
• Study Completion: 2023-06-01
• Study First Submitted: 2023-08-27
• Study First Submitted QC: 2023-08-27
• Last Update Submitted: 2023-08-27
• Study First Posted: 2023-09-01
• Last Update Posted: 2023-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• Completely edentulous male patients wearing heat cured acrylic resin removable prosthesis.
• Patients having denture associated oral stomatitis.
• Healthy patients free of any systemic diseases.

Exclusion Criteria

• Smoker patients.
• Patients suffering from any auto immune or systemic diseases, Temporo-mandibular joint disorder ( TMJ disorders and parafunctional oral habits.
• Patients with a history of radiotherapy or chemotherapy.
• Patients having oral lesions.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group I patients treated with ozonated water	Ozonated water	The patients were used ozonated water as mouth wash for treatment of denture associated oral stomatitis.
Group II patients treated with chlorhexidine mouthwash	Chlorhexidine mouthwash	The patients were used chlorhexidine mouth wash for treatment of denture associated oral stomatitis

Primary Outcome Measures

Name	Time	Method
Candida albicans colonies	day one, 7th day, 14th day and 30th day	The number of Candida albicans forming units (CFU) was used to assess the effect of two types of treatments.

Secondary Outcome Measures

Name	Time	Method
-Evaluation of inflammation and pain grade	day 1, and 30th day	- Evaluation of inflammation and pain grade by questionnaire

Trial Locations

Locations (1)

National Research Centre; 🇪🇬 Cairo, Egypt