To explore the neural network regulatory mechanism mediated by acupuncture in diarrhea-predominant irritable bowel syndrome based on resting-state functional MRI

Not Applicable

Recruiting

• Conditions: diarrhea-predominant irritable bowel syndrome

• Registration Number: ITMCTR2100004533
• Lead Sponsor: The Affiliated Hospital of Nanjing University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1.Meeting the IBS-D Rome IV diagnostic criteria.
2.Age range between 18-55 years old, disease course more than 6 months, right-handed;
3.Baseline IBS-SSS was more than 75;
4.Neither receiveing medication for at least 2 weeks nor receiveing other acupuncture treatments in the past 3 months before taking part in this projject;
5.Volunteer to participate in this research project and sign informed consent;
6.No metal substances in vivo.

Exclusion Criteria

1.Other subtypes that meeting Rome IV diagnostic criteria;
2.Those who with organic intestinal diseases, hyperthyroidism, diabetes and other systemic diseases that affect the motility of the gastrointestinal tract; gastrointestinal surgery history;
3.Taking drugs,acupuncture or other treatments that may affect gastrointestinal function and intervention effectiveness;
4.With cardia-cerebrovascular disease , systemic diseases such as liver, lung, kidney, and mental and psychological diseases, or with mental and psychological diseases;
5.During pregnancy, lactation or within 1 year of childbirth;
6.People with severe fear of needles, metal allergy or allergies; claustrophobia, living implants (such as cochlear implants, vascular clips, etc.), and cardiac pacemakers;
7.Poor compliance; participating in other research projects.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Resting state brain network;

Secondary Outcome Measures

Name	Time	Method
HAMA;IBS-SSS;Bristol Fecal trait scale;IBS-QOL;Number of defecation per week;