Psychoneuroendocrine mechanisms of the regulation of hunger and satiety in obese and anorectic subjects

Recruiting

• Conditions: F50.0; F50.1; E66; Anorexia nervosa; Atypical anorexia nervosa; Obesity

• Registration Number: DRKS00000442
• Lead Sponsor: Medizinische Klinik m.S. PsychosomatikCharité - Universitätsmedizin BerlinCBF/CCM

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 83

Inclusion Criteria

1. anorexic subjects (according ICD-10) (BMI <17,5)
2. obese subjects (BMI >30)
3. normal weight control subjects (BMI 19-25) without relevant somatic disease
4. Healthy normal weight (BMI 19-25) women

Exclusion Criteria

1. Carcinoma
2. Pregnancy during investigation

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Complementary alterations in peptide hormone and enzyme levels (Oxytocin, CRF, Cortisol, CCK, Nesfatin, Ghrelin, Obestatin, PYY, Amylin, Leptin, NPY, CART, GOAT, DPP-IV, Insulin, TNF-alpha, Bombesin, GLP-1) during development towards weight restoration under treatment.

Secondary Outcome Measures

Name	Time	Method
Significant correlations between subjective perceptions (hunger etc.) and psychological variables (anxiety, depression etc.) on the one and peptide hormone plasma levels on the other side (used psychometric instruments: EDI-2 FEV, PSQ, PHQ-9, ICD-10-symptom-rating, COPE, GAD-7, BSF, GBB).<br>Moreover, significant correlations of peptide hormone plasma levels with measures of body composition, energy expenditure and physical activity.