Conditioning of the neuroendocrine system: learned oxytocin responses
Completed
- Conditions
- Het onderzoek wordt bij gezonde personen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvaten voor verklaringsmodellen en therapeutische interventies voor aandoeningen waarbij een verandering in de functie van het endocriene systeem optreedt.not applicable
- Registration Number
- NL-OMON42539
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 99
Inclusion Criteria
healthy, female, premenopausal, 18-35 years old, right-handed, using oral contraceptives
Exclusion Criteria
Somatic and/or psychiatric conditions, (intendend) pregnancy or breast-feeding, heavy use of (illegal) drugs including cannabis and habits of heavy drinking, known sensitivity or hypervigilance to one of the ingredients of the oxytocin or the odor used in this experiment.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is salivary oxytocin level during evocation in the<br /><br>experimental group compared to the placebo group. Oxytocin will be measured<br /><br>four times during the first two evocation sessions (once before and in 5, 20<br /><br>and 30 after the drug or placebo administration) and twice during the third<br /><br>evocation day. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Additional study parameters assessed at baseline and at the evocation phase<br /><br>are: salivary cortisol, pain sensitivity and during the third evocation day<br /><br>only, resting state and task-related (emotional faces, infant crying, and pain<br /><br>stimulation) brain activity, pain sensitivity levels and physiological data<br /><br>using the nociceptive level index during thermal pain stimulation.<br /><br>Additionally, to explore the possible influence of genotype on the effects of<br /><br>conditioning, the 5-HTTLPR genotype and other candidate genotypes will be<br /><br>assessed in saliva.</p><br>