Conditioning of the Cortisol Awakening Response
- Conditions
- The study is conducted in a sample of healthy male volunteers
- Registration Number
- NL-OMON24596
- Lead Sponsor
- eiden University (Health, Medical & Neuropsychology, PI: Prof.dr. Andrea W.M. Evers)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 88
1.Male gender
2.Between 21 and 34 years of age
3.Good understanding of written and spoken Dutch
1.Refusal to give written informed consent
2.Severe somatic or psychiatric conditions that would adversely affect participant’s safety or that might interfere with the study protocol
3.Olfactory impairments
4.Known sensitivity or hypervigilance to one of the ingredients of the scents used in this experiment
5.Heavy use of (illegal) drugs including cannabis and habits of heavy drinking
6.Irregular sleep pattern or sleep problems
7.Use of medication that interferes with the study protocol
8.Factors known to influence the cortisol awakening response:
a.Having an acute illness, or experienced an illness in the past seven days (e.g. influenza, common cold)
b.Experienced jet lag or shift work in the past seven days
c.Use of (oral) glucocorticoid medication
d.HPA-axis related endocrine disorders (e.g., Cushings disease or Addisons disease)
e.Brain damage, particularly hippocampal brain damage
f.Obesity
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary study outcome is the cortisol awakening response (CAR) during evocation in the experimental group compared to the control group, controlling for relevant moderators.
- Secondary Outcome Measures
Name Time Method As secondary analyses, the effect of conditioning on other outcome parameters (e.g., affect) will be explored. Additionally, the impact of personality and sleep parameters (e.g., sleep duration) on the conditionability of the CAR will be explored.