Second Dutch Lupus Nephritis trial

Completed

• Conditions: Proliferative lupus nephritis; Musculoskeletal Diseases; Systemic lupus erythematosus

• Registration Number: ISRCTN34634478
• Lead Sponsor: Sponsor not yet defined (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01-27
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 124

Inclusion Criteria

1. Aged 18 - 70 years
2. Systemic lupus erythematosus (SLE) (presence of at least 4 American College of Rheumatology [ACR]-criteria for SLE)
3. Proliferative lupus nephritis:
3.1. Biopsy proven lupus nephritis World Health Organization (WHO) class III or IV (according to Churg 1995)
3.2. 'Active sediment': greater than 5 erythrocytes per high powered field (HPF) and/or cel cylinders
3.3. Proteinuria greater than 0.5 g/day
4. Adequate contraception
5. Informed consent

Exclusion Criteria

1. Active infection
2. Pregnancy
3. Known allergy for one of the study drugs
4. Malignancy less than 5 years prior to inclusion

Study & Design

• Study Type: Interventional
• Study Design: Not specified