Randomized controlled trial for reduced cumulative immuno-suppression in the treatment of primary membranous nephropathy.
- Conditions
- Health Condition 1: N042- Nephrotic syndrome with diffuse membranous glomerulonephritis
- Registration Number
- CTRI/2020/04/024880
- Lead Sponsor
- Dr Manu Dogra
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1. Either sex with biopsy proven primary MGN.
2. Persistent nephrotic syndrome despite non-immunosuppressive adjuvant treatment for 3 months or earlier due to complications requiring hospitalisation.
3. After informed and written consent.
1.Patients with eGFR < 45 ml/min/1.73m2
2.Prior, active infection including hepatitis B/C and HIV infection
3.Positive for anti-nuclear factor
4.Monoclonal proteins in serum/urine
5.Any suggestion of malignancy on ultrasonography
6.Hypocomplementemia
7.Presence of tubular atrophy and interstitial fibrosis in >1/3rd biopsy area
8.Pre-existing DM
9.Abnormal liver function tests and secondary MN
10.Any immunosuppressive therapy in the last 12 months
11.Female of childbearing age who has a pregnancy plan, or is pregnant, or lactating.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method