ong-term effects of neonatal glucocorticoid treatment on health in later life (follow-up study)

Completed

• Conditions: aandoeningen ontstaan in de perinatale periode; long-term effects of neonatal glucocorticoid treatment

• Registration Number: NL-OMON33574
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 240

Inclusion Criteria

Inclusioncriteria glucocorticoid treated groups:
- Gestational age < 32 weeks
- Bronchopulmonary disease (BPD)
- Completed dexamethasone or hydrocortisone course;Referencegroup:
- Gestational age < 32 weeks
(matching for age, gender, gestational age, severity of IRDS, birth weight)

Exclusion Criteria

Exclusioncriteria glucocorticoid treated groups:
- Dysmaturity
- Glucocorticoid treatment for other indication (i.e. hypotension) or incomplete course
- Intraventricular hemorrhage > grade II according to Papile
- Major congenital anomalies
- Periventricular leukomalacia
- Language barrier;Referencegroup:
- Dysmaturity
- Glucocorticoid treatment for other indication (i.e. hypotension)
- Intraventricular hemorrhage > graad II according to Papile
- Major congenital anomalies
- Periventricular leukomalacia
- Language barrier

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The proposed study will provide data on behavioral, neuropsychological, and<br /><br>motor function. Secondly, basal physiological function (HPA-axis, and immune,<br /><br>cardio-vascular and central nervous system function), markers for<br /><br>cardio-vascular, renal and metabolic disease, and pain sensitivity will be<br /><br>evaluated. Finally, we will determine stress-induced HPA-axis, cardiovascular<br /><br>system and central nervous system responses. Blood cells will also be saved to<br /><br>isolate DNA to perform epigenetic studies in the future.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>