Short versus conventional term glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE trial
Completed
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)RespiratoryChronic obstructive pulmonary disease
- Registration Number
- ISRCTN19646069
- Lead Sponsor
- niversity Hospital Basel, Department of Internal Medicine (Switzerland)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 390
Inclusion Criteria
1. Clinical diagnosis of exacerbated COPD, defined by the presence of at least two of the following:
a. Change in baseline dyspnoea
b. Cough
c. Sputum (levels I ? III according to American Thoracic Society [ATS] or European Respiratory Society [ERS] criteria)
2. Age =40 years
3. History of =20 pack-years of cigarette smoking
Exclusion Criteria
1. Inability to give informed consent
2. Diagnosis of asthma
3. Forced expiratory volume in one second (FEV1) or Forced Vital Capacities (FVC) (Tiffenau) >70% (bedside post-bronchodilator)
4. Radiological diagnosis of pneumonia
5. Coexisting disease making survival of >6 months unlikely
6. Pregnancy or lactation (pregnancy test mandatory for pre-menopausal women)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to next COPD exacerbation
- Secondary Outcome Measures
Name Time Method