Global Reference Ranges - Singapore

Not yet recruiting

• Conditions: Healthy Participants

• Registration Number: NCT07166471
• Lead Sponsor: Perspectum

Brief Summary

We aim to undertake the Global Reference Range Study (GRR) to establish a set of healthy adult reference values for measures of fibroinflammation, fat and size/volumes for the liver, and other abdominal and thoracic organs to assess, compare, and if necessary, propose ethnicity specific reference ranges for these measurements.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-09
• Study Start: 2025-09-01
• Study First Submitted: 2025-09-03
• Study First Submitted QC: 2025-09-03
• Last Update Submitted: 2025-09-03
• Study First Posted: 2025-09-10
• Last Update Posted: 2025-09-10
• Primary Completion: 2027-09
• Study Completion: 2027-09-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Male or female at least 18 years of age
• Self-reported healthy
• Willing and able to give informed consent for participation in the study
• Willing and able to undergo an MRI

Exclusion Criteria

• History of cardiovascular disease as follows:

  • Myocardial infarction
  • Heart failure
  • Cardiomyopathy
  • Stroke
  • Hospital admission/discharge for unstable angina
  • Heart surgery
  • Unstable angina
  • Transient ischemic attack

• Presence of CVD risk factors such as hypertension, hyperlipidaemia, Type 2 diabetes, BMI > 30 kg/m2, smoker (current/ex-smoker)

• History of non-cardiac diseases related to the lungs, liver, kidneys, pancreas or spleen judged by the study investigator as therefore unsuitable to participate in the study

• The participant may not enter the study if they have any contraindication to magnetic resonance imaging (standard MRI exclusion criteria including pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia)

• Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the reference values for liver fibroinflammation in healthy adults from different ethnic groups.	24 months