Intraoperative Cell Salvage and Retrograde Autologous Priming in Patients Undergoing Isolated Coronary Bypass Grafting and Conventional Aortic Valve Replacement.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Surgery
- Sponsor
- University Hospital Schleswig-Holstein
- Enrollment
- 200
- Locations
- 2
- Primary Endpoint
- number of red blood cell concentrates
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
In recent years Patient Blood Management (PBM) has developed into a multifactorial and interdisciplinary concept that focuses on individualized and optimized hemotherapy. Of course, this also applies to the cardiac surgery area (1). In this context, the quality of the intraoperative PBM can be represented by patients scheduled for isolated coronary artery bypass grafting (CABG) and isolated aortic valve replacement (AVR). In a prospective, observational "before-and-after" protocol, the investigators analysed the impact of the combined use of retrograde autologous priming (RAP) and cell salvage on intraoperative usage of red blood cell concentrates (RBC) (2).
Detailed Description
200 patients (CABG or AVR) will be monitored using local standard of care in these patients without cell salvage and RAP (control group, CG), followed by 200 patients with cell salvage and RAP (study group, SG). Both groups are defined by elective surgery and hemodynamically stable patients prior to the onset of the cardiopulmonary bypass (CPB). Based on our own data and current data from the literature, the investigators assume that the use of MAT in combination with RAP leads to at least an intraoperative reduction of the erythrocyte consumption of 15%. Consequently, the investigators calculated a case number of approximately 200 patients per group. The study is set up with a control group under previous standard therapy. The data is recorded and analyzed descriptively. Qualitative comparisons will be made in the discussion of previously published data.
Investigators
Dr. Jochen Renner
Prof. Dr. med. Jochen Renner
University Hospital Schleswig-Holstein
Eligibility Criteria
Inclusion Criteria
- •scheduled for cardiac surgery
- •informed written consent
Exclusion Criteria
- •rejection by the patient
- •switching to another procedure
Outcomes
Primary Outcomes
number of red blood cell concentrates
Time Frame: through study completion, an average of 1 year
use of RBC
Secondary Outcomes
- postoperative complications(through study completion, an average of 1 year)
- length of stay in hospital(through study completion, an average of 1 year)
- hospital mortality(through study completion, an average of 1 year)