Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome

Not Applicable

Completed

• Conditions: Polycystic Ovary Syndrome
• Interventions: Drug: Letrozole

• Registration Number: NCT05075863
• Lead Sponsor: Nishtar Medical University

Brief Summary

We aimed this study to determine and compare frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate as published literature shows variations.

Detailed Description

Discrepancy between ovulation induction rate and pregnancy rate is related to anti-estrogenic effects on cervical mucus and endometrium and long acting gonadotrophins are more effective than clomiphene citrate. This study was aimed at comparing frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate.

Study Timeline

• Study Start: 2021-01-01
• Primary Completion: 2021-06-30
• Study Completion: 2021-06-30
• Study First Submitted: 2021-09-28
• Status Verified: 2021-10
• Study First Submitted QC: 2021-10-08
• Last Update Submitted: 2021-10-12
• Study First Posted: 2021-10-13
• Last Update Posted: 2021-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 78

Inclusion Criteria

• Diagnosed cases of polycystic ovarian syndrome.

Exclusion Criteria

• All women having endocrine disorders like thyroid disorders.
• Women having hyperprolactinemia.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Clomiphene Citrate	Letrozole	A total of 39 women were given clomiphene citrate, 100mg from 3 to 7 days of menstrual cycle. All patients underwent transvaginal scan (TVS) so that efficacy could be evaluated (ovulation occurs on 14 day of menstrual cycle after a treatment of 5 days of both groups. Induction of ovulation was assessed by TVS. If follicle of \>2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled.
Letrozole	Letrozole	A total of 39 women were given letrozole, 5mg from day 3 to 7 of menstrual cycle. All patients underwent transvaginal scan (TVS) so that efficacy could be evaluated (ovulation occurs on 14 day of menstrual cycle after a treatment of 5 days of both groups. Induction of ovulation was assessed by TVS. If follicle of \>2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled.

Primary Outcome Measures

Name	Time	Method
Induction of ovulation was assessed by Transvaginal scan (TVS)	12 to 16 days.	Induction of ovulation was assessed by TVS. If follicle of \>2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled

Trial Locations

Locations (1)

Nishtar Medical University Hospital; 🇵🇰 Multan, Punjab, Pakistan