Letrozole Versus Laparoscopic Ovarian Drilling in Polycystic Ovary Syndrome
- Registration Number
- NCT03009838
- Lead Sponsor
- Assiut University
- Brief Summary
Polycystic ovary syndrome is the major cause of anovulatory infertility. Clomiphene citrate is the most commonly used oral agent for ovulation induction in this group, but there are some drawbacks with the use of it.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 150
Inclusion Criteria
- History of at least one year of infertility either primary or secondary.
- Body mass index: 25-35
- Normal fallopian tubes
- Normal semen analysis of the husband
- Women who will accept to participate in the study
Exclusion Criteria
- Body mass index above 35
- Contraindication to general anesthesia
- Previous laparoscopic drilling
- Presence of other causes of infertility
- Women who had received metformin, gonadotrophin, oral contraceptives or other hormonal drugs during the preceding 6 months
- Women who intended to start a diet program
- Women who will refuse to participate in the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description letrozole Letrozole letrozole 2.5 mg oral tablets will be started daily from day 3 of the menses for 5 days in a dose of 5 mg/day laparoscopic drilling ovarian drilling laparoscopy will be performed using three-puncture technique. Each ovary will be cauterized at four points, each for 4 seconds at 40 W for a depth of 4 mm with a mixed current, using a monopolar electrosurgical needle
- Primary Outcome Measures
Name Time Method The ovulation rate 3 months
- Secondary Outcome Measures
Name Time Method The mid-cyclic endometrial thickness one day
Trial Locations
- Locations (1)
Assiut University
🇪🇬Assiut, Egypt