NCT01710280已完成不适用
Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- Incremental AUC (change from baseline in overall response) for plasma triacylglycerol concentrations
研究概览
简要总结
The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy males
- •Non-smokers
- •Aged 40-70 years
- •Fasting TAG concentrations ≥1.5 mmol/L.
排除标准
- •Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease.
- •Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.
- •History of substance abuse or alcoholism (previous weekly alcohol intake >60 units/men)
- •Current self-reported weekly alcohol intake exceeding 28 units
- •Allergy or intolerance to any component of test meals
- •Unwilling to restrict consumption of any source of fish oil for the length of the study
- •Weight change of >3kg in preceding 2 months
- •Body Mass Index <20 and >35 kg/m2
- •Fasting blood cholesterol > 7.8 mmol/L
- •Current cigarette smoker.
- •Current use of lipid lowering medication
研究组 & 干预措施
Native palm olein
Active Comparator
75 g native palm olein
干预措施: High-fat meal containing native palm olein (Dietary Supplement)
Interesterified palm olein
Experimental
75 g interesterified palm olein
干预措施: High-fat meal containing interesterified palm olein (Dietary Supplement)
结局指标
主要结局
Incremental AUC (change from baseline in overall response) for plasma triacylglycerol concentrations
时间窗: 1-6 h post-meal
次要结局
- Incremental AUC for plasma non-esterified fatty acid concentrations(1-6 h post-meal)
- Changes from baseline in digital volume pulse(2,4,5,6 h post-meal)
- Changes from baseline in blood pressure(2,4,5,6 h post-meal)
研究者
Dr Wendy Hall
Lecturer in Nutritional Sciences
King's College London
研究点 (2)
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