Palmitic Acid in the Sn-2 Position of Triacylglycerols and Postprandial Lipemia

Not Applicable

Completed

• Conditions: Healthy Men; Raised Fasting Plasma Triacylglycerol Concentrations
• Interventions: Dietary Supplement: High-fat meal containing native palm olein; Dietary Supplement: High-fat meal containing interesterified palm olein

• Registration Number: NCT01710280
• Lead Sponsor: King's College London

Brief Summary

The purpose of this study is to determine whether high-fat meals rich in palmitic acid in the sn-2 position decrease lipaemia in men aged 40-70 y with higher than optimal fasting triacylglycerol concentrations.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-05
• Primary Completion: 2011-12
• Study Completion: 2012-06
• Study First Submitted: 2012-10-17
• Study First Submitted QC: 2012-10-18
• Study First Posted: 2012-10-19
• Status Verified: 2019-09
• Last Update Submitted: 2019-09-12
• Last Update Posted: 2019-09-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 11

Inclusion Criteria

• Healthy males
• Non-smokers
• Aged 40-70 years
• Fasting TAG concentrations ≥1.5 mmol/L.

Exclusion Criteria

• Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease.
• Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption.
• History of substance abuse or alcoholism (previous weekly alcohol intake >60 units/men)
• Current self-reported weekly alcohol intake exceeding 28 units
• Allergy or intolerance to any component of test meals
• Unwilling to restrict consumption of any source of fish oil for the length of the study
• Weight change of >3kg in preceding 2 months
• Body Mass Index <20 and >35 kg/m2
• Fasting blood cholesterol > 7.8 mmol/L
• Current cigarette smoker.
• Current use of lipid lowering medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Native palm olein	High-fat meal containing native palm olein	75 g native palm olein
Interesterified palm olein	High-fat meal containing interesterified palm olein	75 g interesterified palm olein

Primary Outcome Measures

Name	Time	Method
Incremental AUC (change from baseline in overall response) for plasma triacylglycerol concentrations	1-6 h post-meal

Secondary Outcome Measures

Name	Time	Method
Incremental AUC for plasma non-esterified fatty acid concentrations	1-6 h post-meal
Changes from baseline in digital volume pulse	2,4,5,6 h post-meal
Changes from baseline in blood pressure	2,4,5,6 h post-meal

Trial Locations

Locations (1)

Diabetes & Nutritional Sciences Division, King's College London.; 🇬🇧 London, United Kingdom