A study to compare the effectiveness of two drugs, Dexamethasone versus Methylprednisolone in the treatment of moderate Covid 19 patients
Not Applicable
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2020/12/029894
- Lead Sponsor
- SRM Medical College Hospital and Research Centre
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Hospitalized patients with moderate SARS-COV-2 infection laboratory confirmed by RT-PCR
(Moderate COVID 19- SPO2 <94% Under room air and requiring supplemental oxygen for hypoxemia
Respiratory rate 24-30/min
NLR >5
CRP 50-100 mg/l
Serum ferritin 600-1500 ng/ml
Serum LDH 300-500 IU/l
D Dimer 0.5-1.0 mic/ml
IL-6 20-100 pg/ml
CT chest showing 25-75% infiltrates)
Exclusion Criteria
1.Patients with mild and severe covid pneumonia
2.Patients who are already on steroid treatment for any underlying condition
3.Patients already started on antivirals
4.Pregnant or lactating women
5.Any known contraindication to short term corticosteroid like severe immunosuppression, HIV infection or any other immunosuppressant usage
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Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mortality during hospital stayTimepoint: Day 1 - Day 7
- Secondary Outcome Measures
Name Time Method 1.Time taken to wean off supplemental oxygen <br/ ><br>2.Need for mechanical ventilationTimepoint: Day 1 of enrollment in the study to Day 7