Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
Not Applicable
Recruiting
- Conditions
- HematopoiesisPulmonary Embolism
- Interventions
- Biological: blood sample
- Registration Number
- NCT04711746
- Lead Sponsor
- Centre Hospitalier Universitaire, Amiens
- Brief Summary
The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 544
Inclusion Criteria
- For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening.
- For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.
Exclusion Criteria
- Age superior to 65 years old,
- Active cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Previous proximal provoked pulmonary embolism blood sample - Previous proximal unprovoked pulmonary embolism blood sample -
- Primary Outcome Measures
Name Time Method Variation of CHIP markers between patients groups up to 2 years Variation of CHIP markers (clonal hematopoiesis of indetermined prognosis ) between patients groups.
CHIP concept have been defined as a mutation of preleukemic genes at an allelic variation inferior to 2% associated with normal complete blood count.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
CHU Amiens
🇫🇷Amiens, France