Management of Polycystic Ovarian Syndrome in young wome
- Conditions
- Polycystic Ovary Syndrome PCOS
- Registration Number
- PACTR201710002641118
- Lead Sponsor
- Emaduldin Seyam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 200
A randomized, double-blind controlled study was performed using combined Simvastatin and metformin with PCOS unmarried women in a tertiary care centre in Upper Egypt. The diagnosis of PCOS was based on the availability of the three diagnostic criteria of the Rotterdam consensus, namely clinical and biochemical evidence of hyperandrogenaemia (Ferriman-Gallwey score (FGS), free androgen index (FAI) respectively), oligomenorrhea or amenorrhea and polycystic ovaries on transabdominal ultrasound
Women recruited had no concurrent illness, and were not on any prescription or over-the-counter medication which might affect insulin sensitivity, lipids or ovarian function including hormonal contraceptives for the preceding six months. 21-hydroxylase deficiency, hyperprolactinaemia, Cushing¿s disease and androgen-secreting tumors were excluded by appropriate tests. All women were young unmarried and not planning to marry at least till the end of study period. Recruited women were advised not to change their lifestyle, including physical activity or dietary habits, during the study period
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Spontaneous ovulation improvement
- Secondary Outcome Measures
Name Time Method Improvement of the clinical, and biochemical abnormalities assocaited with PCOS