The Initial Effect of Training on Mitochondrial Function in Patients With Intermittent Claudication
Completed
- Conditions
- Intermittent Claudication
- Interventions
- Behavioral: exercise
- Registration Number
- NCT01842412
- Lead Sponsor
- Norwegian University of Science and Technology
- Brief Summary
The hypothesis of this study is that one bout of leg exercise gives acute qualitative changes in mitochondrial function in claudication. Final purpose is to determine the optimal exercise frequency in treatment of claudication.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- A history of any type of uni- or bilateral exertion leg pain.
- A maximal claudication distance that is less than 300 meter
- Diagnosed with intermittent claudication secondary to vascular insufficiency
- An ankle-brachial index between 0.4 and 0.9.
- Lives in Trondheim
Exclusion Criteria
- Diagnosed with critical limb ischemia
- ankle-brachial index > 0.90 or < 0.4
- Limited exercise tolerance
- Warfarin or heparin usage
- Diabetes mellitus
- Underwent a vascular intervention in the last 3 months
- Active cancer, renal- or liver disease.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description healthy exercise - claudication exercise -
- Primary Outcome Measures
Name Time Method Mitochondrial function One day respirometry
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department for circulation and medical imaging, NTNU
🇳🇴Trondheim, Postboks 8905, Norway