Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.

Not Applicable

Not yet recruiting

• Conditions: Lung Disorder
• Interventions: Procedure: VESPA; Procedure: conventional mechanical ventilation

• Registration Number: NCT05720845
• Lead Sponsor: Guangzhou Institute of Respiratory Disease

Brief Summary

This trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing interventional pulmonology procedures under general anesthesia. Ventilatory strategy to prevent reduce the intra-procedural development of atelectasis during interventional pulmonology procedures under general anesthesia.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-01
• Study First Submitted: 2023-01-12
• Study First Submitted QC: 2023-01-31
• Last Update Submitted: 2023-01-31
• Study Start: 2023-02-08
• Study First Posted: 2023-02-09
• Last Update Posted: 2023-02-09
• Primary Completion: 2025-01-18
• Study Completion: 2025-03-18

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Adult patients undergoing interventional pulmonology procedures with radial probe endobronchial ultrasound (RP-EBUS) for peripheral lung lesions
• Recent (< 4 weeks) chest computed tomography (CT) performed prior to the bronchoscopy

Exclusion Criteria

• Patients with baseline lung consolidation, interstitial changes or lung masses (> 3 cm in diameter) in dependent areas of the lung (right/left [R/L] B6, 9, or 10 bronchial segments) as seen on most recent CT
• History of primary or secondary spontaneous pneumothorax

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
VESPA	VESPA	ventilatory strategy to prevent atelectasis for General Anesthesia
conventional mechanical ventilation	conventional mechanical ventilation	Conventional mechanical ventilation for General Anesthesia

Primary Outcome Measures

Name	Time	Method
Presence or absence of new atelectasis for each segment	During bronchoscopy, an average of 1 hour.	The proportion of patients identified as developing intraprocedural atelectasis by radial probe endobronchial ultrasound (RP-EBUS)

Secondary Outcome Measures

Name	Time	Method
Ventilation-induced complications	Within 48 hours of bronchoscopy
Bronchoscopy-induced complications	Within 48 hours of bronchoscopy
Assess the regional ventilation distribution by Electrical impedance tomography (EIT)	During bronchoscopy, an average of 1 hour.

Trial Locations

Locations (1)

Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, Guangdong, China