Comparison of 2 Ventilatory Support Strategies During Coronavirus Disease 2019 (Covid-19) Pneumonia

Completed

• Conditions: COVID-19
• Interventions: Procedure: Invasive ventilation strategy; Procedure: Non-invasive ventilation strategies

• Registration Number: NCT04799691
• Lead Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Brief Summary

This retrospective monocentric study compares 2 ventilatory support strategies on outcomes (length of stay, intubation, mortality) in patients admitted in Intensive Care Unit with Covid-19 related pneumonia : invasive strategy used during the first period and non-invasive strategies (Continuous Positive Airway Pressure, High Flow Nasal Canula, Prone Position) used during the second period.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-02-01
• Study First Submitted: 2021-03-15
• Study First Submitted QC: 2021-03-15
• Study First Posted: 2021-03-16
• Primary Completion: 2022-01-15
• Study Completion: 2022-01-15
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-10
• Last Update Posted: 2022-10-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 133

Inclusion Criteria

• Patient with confirmed SARS COV2 infection
• Acute Respiratory Distress Syndrome
• Patient more than 18 year old

Exclusion Criteria

• Intensive Care Unit admission for extra pulmonary failure
• "Do Not Reanimated" order
• Patient from another Intensive Care Unit
• Patient objection
• Judicial protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Invasive strategy group	Invasive ventilation strategy	Patients admitted in ICU with Covid-19 related pneumonia during COVID19 first period.
Non-invasive strategy group	Non-invasive ventilation strategies	Patients admitted in ICU with Covid-19 related pneumonia during COVID19 second period.

Primary Outcome Measures

Name	Time	Method
Length of stay in ICU	At the moment of ICU discharge or death, up to 3 month	Number of days spent in ICU

Secondary Outcome Measures

Name	Time	Method
Mortality	At the moment of ICU discharge or death, up to 3 month	Rate of patients alive at the moment of intensive care unit discharge
Complications	At the moment of ICU discharge or death, up to 3 month	Number of complications during intensive care unit stay

Trial Locations

Locations (1)

Hôpital Sainte Musse; 🇫🇷 Toulon, Var, France