Autonomic and Metabolic Response to Cardiac Rehabilitation After Acute MI

Recruiting

• Conditions: Acute Myocardial Infarction: Rehabilitation Phase

• Registration Number: NCT06298513
• Lead Sponsor: Istituto Auxologico Italiano

Brief Summary

Ischemic heart disease remains the leading cause of death in the western world. The beneficial effects of cardiac rehabilitation on the evolution of ischemic heart disease are known, but the effects of rehabilitation on the metabolic processes of the patients are so far poorly understood. Metabolomics is the qualitative/quantitative analysis of the body's metabolic responses to pathophysiological stimuli or genetic alterations. Metabolic changes caused by physical activity have been demonstrated in obese and diabetic patients and in athletes. Aim of the study is to evaluate whether cardiac rehabilitation after a first myocardial infarction induces changes in the metabolic state of patients, and whether these changes may be related with changes in the usual risk factors (i.e. glyco-lipidic profile, natriuretic peptides, homocysteine).

Detailed Description

Not available

Study Timeline

• Study Start: 2023-05-02
• Status Verified: 2024-03
• Study First Submitted: 2024-03-01
• Study First Submitted QC: 2024-03-01
• Last Update Submitted: 2024-03-01
• Study First Posted: 2024-03-07
• Last Update Posted: 2024-03-07
• Primary Completion: 2025-04
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Male
• Target Recruitment: 25

Inclusion Criteria

• recent first acute myocardial infarction

Exclusion Criteria

• severe diabetes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in purine after rehabilitation	Baseline and after 6 weeks of rehabilitation	The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.
Changes in histidine after rehabilitation	Baseline and after 6 weeks of rehabilitation	The concentration of purine will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis
Changes in galactose after rehabilitation	Baseline and after 6 weeks of rehabilitation	The concentration of galactose will be calculated after rehabilitation, and compared to its baseline concentration by a paired T test analysis.

Trial Locations

Locations (1)

Istituto Auxologico Italiano; 🇮🇹 Milan, Italy