Effects of different anaesthetic techniques on neutrophil lymphocyte ratio and monocyte lymphocyte ratio in patients undergoing major non-cardiac surgery: An observational analytical study

This is an observational analytical study where the effects of different anaesthetic techniques on neutrophil lymphocyte ratio and monocyte lymphocyte ratio in patients undergoing major non cardiac surgery will be studied in various time Line. Three groups allocated (Total intravenous anesthesia, neuraxial block, balance anesthesia) and blood sample of CBC will be sent preoperatively, at the end of surgery, 6 hours and 24 hours after surgery. Total of 300 patient of either sex of age group 18 to 70 years belonging to ASA physical status 1 and 2, excluding patients who have any contraindication to spinal anesthesia and General anesthesia  patients with coexisting acute infection and sepsis, patients on recent chemotherapy, patients on chronic treatment with steroids or immunosuppressants, patients who are morbidly obese and have autoimmune disease, patients underwent blood transfusion for < 1 week, patients not willing to give consent.