Influence of vitamin B1 suplementation in oxidative stress, energetic metabolism and mortality among patients with septic shock
Not Applicable
- Conditions
- Septic shockthiamine deficiency
- Registration Number
- RBR-9m6bny
- Lead Sponsor
- Faculdade de Medicina de Botucatu
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
age over 18 years; both sexes; hospitalized with the diagnosis of septic shock at the Intensive Care Unit of Hospital das Clínicas of Botucatu Medical School; signing the Free and Informed Consent Term.
Exclusion Criteria
Delayed diagnosis of septic shock (time greater than 24 h); pregnancy; noradrenaline dose > 2.0 mcg/kg/min, vasopressor-dependence for less than 24 h; patients with clinical indication of supplementation thiamine; confirmed encephalic death; patients in palliative care; association with other types of shock (cardiogenic, hemorrhagic or hypovolemic).
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome will be mortality in the Intensive Care Unit (ICU) and hospital mortality. Patients will be monitored daily during their ICU and hospital stay, until discharge or death.
- Secondary Outcome Measures
Name Time Method ength of ICU and hospital stay. Patients will be monitored daily during their ICU and hospital stay, until discharge or death. The total length of stay will be counted in days.;Duration of mechanical ventilation. Patients will be monitored daily during their ICU and hospital stay, and the duration of mechanical ventilation will be counted in days, considering the period between the first and last day of use.;Duration of vasopressor use. Patients will be monitored daily during their ICU and hospital stay, and the duration of vasopressor need will be counted in days, considering the period between the first and last day of use.