Effect of thiamine on vasopressor requirement in patients with septic shock : A randomized control trial

Phase 1

• Conditions: Septic shock; Thiamine

• Registration Number: TCTR20180310001
• Lead Sponsor: Hospital fund

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-03-10
• Study Completion: 2019-01-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Terminated (Halted Prematurely)
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

1. Age over 18 years
2. On vasopressor duration between 1-24 hours
3. Inform consent
4. Suspected infection

Exclusion Criteria

1.recieve thiamine > 100 mg last 24 hours
2. Thiamine allergy or anaphylaxis
3. Cancer that survival rate < 50% at 6 months
4. Who was agnosed cardiac beriberi, peripheral beriberi, korsakoff syndrome, re-feeding

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vasopressor free day for 7 days 24 hours Number of day free vasopressor

Secondary Outcome Measures

Name	Time	Method
actate reduction 24 h 24 hr Variable data,Vasopressor dependency reduction 24 h 24 h Variable data,SOFA score change for 7 days 7 days Variable data,Vasopressor dependency index 7 days Variable data,28 day mortality 28 day Variable data