The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis

Phase 4

• Conditions: Tuberculous Meningitis
• Interventions: Drug: Dexamethasone acetate

• Registration Number: NCT02588196
• Lead Sponsor: Hui Bu

Brief Summary

The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2015-10
• Study First Submitted: 2015-10-26
• Study First Submitted QC: 2015-10-26
• Study First Posted: 2015-10-27
• Last Update Submitted: 2015-10-27
• Last Update Posted: 2015-10-29
• Study Start: 2015-11
• Primary Completion: 2018-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

patients were eligible to enter the study if they met the diagnositic criteria for possible, probable or definite Tuberculosis meningitis(TBM).

Exclusion Criteria

Patients were excluded if they were infected with HIV, diagnosed as carcinomatous meningitis, viral meningitis, purulent meningitis, cryptococcus meningitis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
treatment of dexamethasone group	Dexamethasone acetate	-

Primary Outcome Measures

Name	Time	Method
MRI	6 month	whether MRI show infarction, hydrocephalus, meningeal enhancement
changes of clinical symptoms	1 year	headache duration, duration of fever,presence of cranial nerve damage
changes of cerebrospinal fluid	1 year